1 paper1 finding
Acute injury
mixedin silico1
Acute injury is associated with cellular age in silico.
“observed dynamic, reversible shifts in cellular age following acute injury.”
In silicoFollowing acute injuryretina
bioRxiv (Cold Spring Harbor Laboratory)11 Sep 2025Preprint
An observational analysis of 126 whole-blood DNA profiles identified 409 genes with age-linked changes in chemical marks throughout life.An observational analysis of 126 whole-blood DNA profiles identified 409 genes with age-linked changes in chemical marks throughout life.
Male mice carrying the same diabetes-linked mutation developed diabetes on a mixed genetic background, but maintained normal blood sugar on another background.Male mice carrying the same diabetes-linked mutation developed diabetes on a mixed genetic background, but maintained normal blood sugar on another background.
In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.
In cultured fibroblasts and mice, apolipoprotein D triggers SUN1 accumulation, reinforcing a signaling cycle that alters gene expression and cellular polarity.In cultured fibroblasts and mice, apolipoprotein D triggers SUN1 accumulation, reinforcing a signaling cycle that alters gene expression and cellular polarity.
Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.