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Yamanaka factor induction

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Milky Way Research Foundation
  • Animals1

Outcomes

2

Glial molecular age

no changein animals1

1 study

  1. Yamanaka factor induction has no effect on glial molecular age.

    “Targeted Müller glia-specific induction of Yamanaka factors reduced molecular age in rod photoreceptors and bipolar cells without altering glial age.”

    AnimalsTargeted Müller glia-specific inductionMüller glia

    Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging

    bioRxiv (Cold Spring Harbor Laboratory)11 Sep 2025Preprint

More on Glial molecular age

Molecular age in rod photoreceptors and bipolar cells

downin animals1

1 study

  1. Yamanaka factor induction decreases molecular age in rod photoreceptors and bipolar cells.

    “Targeted Müller glia-specific induction of Yamanaka factors reduced molecular age in rod photoreceptors and bipolar cells without altering glial age.”

    AnimalsTargeted Müller glia-specific inductionrod photoreceptors and bipolar cells

    Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging

    bioRxiv (Cold Spring Harbor Laboratory)11 Sep 2025Preprint

More on Molecular age in rod photoreceptors and bipolar cells

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