Chromatin accessibility
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4Activity and insulin resistance show opposite muscle gene links
In an observational study of 263 Finnish individuals, higher physical activity and lower insulin resistance were both linked to higher proportions of…In an observational study of 263 Finnish individuals, higher physical activity and lower insulin resistance were both linked to higher proportions of Type 1 nuclei.
A protein promoted hair cell regeneration in newborn mice
Genetically modified newborn mice produced extra TRIM71, a protein that binds RNA, which promoted spontaneous regrowth of sound-detecting cells in the…Genetically modified newborn mice produced extra TRIM71, a protein that binds RNA, which promoted spontaneous regrowth of sound-detecting cells in the inner ear.
Estrogen-responsive variants interact with reproductive risk factors
In 13,026 post-menopausal cases and 108,265 controls, an estrogen-responsive polygenic score interacted with reproductive traits including age at…In 13,026 post-menopausal cases and 108,265 controls, an estrogen-responsive polygenic score interacted with reproductive traits including age at first birth (p=0.0052).
Kidney tubular epithelial cells drive accelerated epigenetic aging in disease
A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair.A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair.