β-cell mass

1. Crowded litter decreases β-cell mass in mice.

   “β-cell mass was significantly reduced in the CL male mice”

   Animalsmales

   Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis

   American journal of physiology. Endocrinology and metabolism·15 Apr 2014

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1. Caloric restriction increases β-cell mass in rats.

   “Moreover, CR animals showed the increased β-cell mass and proliferation of β-cells in pancreas.”

   Animalspancreas24 weeksmalesn = 16

   Calorie restriction from a young age preserves the functions of pancreatic β cells in aging rats

   The Tohoku journal of experimental medicine·1 Aug 2012

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1. Body weight is associated with β-cell mass in rats (r = 0.98, P < 0.001).

   “showed a strong and significant linear correlation with body weight (r = 0.98, P < 0.001).”

   Animals

   Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy

   Diabetes·1 Aug 2000