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Crowded litter

Intervention

2 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

  • 2 independent labs in 1 country
  • 1 finding against
  • Funders: National Institute on Aging and 2 more
  • Animals2

Outcomes

6

Lifespan

upin mice2

2 studies

  1. Crowded litter extends lifespan in mice.

    “Increasing mouse litter size [crowded litter (CL)] presumably imposes a transient nutrient stress during suckling and extends lifespan through unknown mechanisms.”

    Reviewduring suckling

    Long-lived crowded-litter mice have an age-dependent increase in protein synthesis to DNA synthesis ratio and mTORC1 substrate phosphorylation

    American journal of physiology. Endocrinology and metabolism9 Sep 2014

  2. Crowded litter extends lifespan in mice.

    “limiting nutrient availability in the first 3 wk of life [by increasing the number of pups in the crowded-litter (CL) model] leads to extension of mean and maximal lifespan”

    Reviewin the first 3 wk of life

    Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis

    American journal of physiology. Endocrinology and metabolism15 Apr 2014

DNA synthesis

downin mice1upin mice1

1 study

  1. Crowded litter decreases DNA synthesis in mice.

    “Seven-month CL had less DNA synthesis than controls in heart”

    Animalsheart

    Long-lived crowded-litter mice have an age-dependent increase in protein synthesis to DNA synthesis ratio and mTORC1 substrate phosphorylation

    American journal of physiology. Endocrinology and metabolism9 Sep 2014

  2. Crowded litter increases DNA synthesis in mice.

    “Compared with controls, 4-mo CL had greater DNA synthesis in gastroc complex”

    Animalsgastrocnemius complex

    Long-lived crowded-litter mice have an age-dependent increase in protein synthesis to DNA synthesis ratio and mTORC1 substrate phosphorylation

    American journal of physiology. Endocrinology and metabolism9 Sep 2014

More on DNA synthesis

β-cell mass

downin mice1

1 study

  1. Crowded litter decreases β-cell mass in mice.

    “β-cell mass was significantly reduced in the CL male mice”

    Animalsmales

    Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis

    American journal of physiology. Endocrinology and metabolism15 Apr 2014

More on β-cell mass

Insulin sensitivity

upin mice1

1 study

  1. Crowded litter increases insulin sensitivity in mice.

    “Glucose and insulin tolerance tests show an increase in insulin sensitivity in 6 mo old CL male mice”

    Animalsmales

    Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis

    American journal of physiology. Endocrinology and metabolism15 Apr 2014

Oxygen consumption

upin mice1

1 study

  1. Crowded litter increases oxygen consumption in mice.

    “CL mice are significantly leaner and consume more oxygen relative to control mice.”

    Animalsthroughout adult life

    Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis

    American journal of physiology. Endocrinology and metabolism15 Apr 2014

Adiposity

downin mice1

1 study

  1. Crowded litter decreases adiposity in mice.

    “At weaning and then throughout adult life, CL mice are significantly leaner and consume more oxygen relative to control mice.”

    Animalsthroughout adult life

    Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis

    American journal of physiology. Endocrinology and metabolism15 Apr 2014

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