2 papers3 findings
Polycystic ovary syndrome
upin humans1
Polycystic ovary syndrome is associated with age at menopause in humans.
“Many risk-increasing loci were associated with later age at menopause”
Humans
Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome
Nature genetics23 Apr 2026
Occipital lobe volume
downin humans1
Age at menopause is associated with occipital lobe volume in humans (β = -0.52 cm3, 95% CI -1.01 to -0.03; p = 0.04).
“Earlier age at menopause was associated with smaller occipital lobe volume (β = -0.52 cm3, 95% CI -1.01 to -0.03; p = 0.04)”
Humanspostmenopausaloccipital lobefemalesn = 361
Reproductive factors and brain volume in community-dwelling individuals: the Ohasama Study
Environmental health and preventive medicine1 Jan 2026
Klemera-Doubal biological age
upin humans1
Age at menopause is associated with Klemera-Doubal biological age in humans (β = 0.69, 95% CI 0.39–0.98).
“Earlier age at menopause was associated with accelerated comprehensive BA in UKB (< 40 years: β = 0.69, 95% CI = 0.39, 0.98”
Humansfemales
BMC medicine6 Aug 2025
Office of the President, University of CaliforniaUS$1.8mJapan Society for the Promotion of ScienceJP¥17.6mCanadian Institutes of Health Research (CIHR) Project GrantCA$2.2k
Synergistic effects of age at menopause and vascular risk on cognition
Canadian Institutes of Health Research (CIHR) Project GrantSunnybrook Health Science CentreCA$2.2k2023–2024
Does the co-use of tobacco and cannabis increase the risk of earlier age at menopause?
Office of the President, University of CaliforniaUniversity of California, San FranciscoUS$914.2k2022–2026
Does the co-use of tobacco and cannabis increase the risk of earlier age at menopause?
Office of the President, University of CaliforniaNorthern California Institute for Research and EducationUS$914.2k2022
Japan Society for the Promotion of ScienceGifu UniversityJP¥17.6m2020–2024
Among 80,148 women without a reported endometriosis diagnosis before menopause, 1.1% reported their first diagnosis after menopause.Among 80,148 women without a reported endometriosis diagnosis before menopause, 1.1% reported their first diagnosis after menopause.
Compared with never-users, hormone therapy ever-users had adjusted hazard ratios, which compare event rates over time, of 0.72 for breast cancer death and 1.17 for…Compared with never-users, hormone therapy ever-users had adjusted hazard ratios, which compare event rates over time, of 0.72 for breast cancer death and 1.17 for diagnosis.
A cross-sectional study of 200 postmenopausal women found neck artery plaque in 12% of women with HIV versus 3% of HIV-negative women.A cross-sectional study of 200 postmenopausal women found neck artery plaque in 12% of women with HIV versus 3% of HIV-negative women.
All-cause mortality was higher with premature ovarian failure (adjusted hazard ratio 2.50), depression (1.64), and both conditions combined (5.04) versus neither.All-cause mortality was higher with premature ovarian failure (adjusted hazard ratio 2.50), depression (1.64), and both conditions combined (5.04) versus neither.