Epigenetic aging
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23Direct conversion to neural stem cells de-ages human blood cells
Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.
Epigenetic age links to higher dementia risk in older adults
In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia…In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia (hazard ratio 1.30).
Optimized Nutri-Dense meals versus a low-carbohydrate high-fat diet: an exploratory randomized controlled trial
Early life stress accelerates epigenetic aging in zebra finches
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.
Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer…The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
Glymphatic dysfunction is linked to brain aging in schizophrenia
In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and…In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and epigenetic aging.
Speech age gaps track dementia phenotypes and biological aging
In 2,928 individuals across five Latin American countries, speech age gaps tracked dementia diagnoses, brain age, social exposome, and epigenetic…In 2,928 individuals across five Latin American countries, speech age gaps tracked dementia diagnoses, brain age, social exposome, and epigenetic aging clocks.