Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung…Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung cancer patient-derived organoids.
Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process. In human blood cells from donors ranging from neonatal to 101 years of age, researchers tracked cellular rejuvenation during direct lineage…
In a randomized trial, 12 weeks of the mind-body exercise lowered systolic blood pressure by 7.2 mmHg compared with habitual lifestyle.In a randomized trial, 12 weeks of the mind-body exercise lowered systolic blood pressure by 7.2 mmHg compared with habitual lifestyle. Forty-six sedentary postmenopausal women enrolled in a 12-week randomized controlled trial evaluating Baguazhang, a traditional Chinese mind-body…
In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune…In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron homeostasis. In aged mice, exposure to the fungus Kazachstania pintolopesii accelerates splenic senescence, according to a study…
Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident…Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident Alzheimer’s disease risk. In human health records and cortical organoids, researchers evaluated aspirin as a repurposed candidate against…
The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway. In female mice experiencing reproductive aging, administration of the peptide elamipretide increased litter size and ameliorated age-related declines in oocyte…
In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ±…In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ± 0.02 to 1.37 ± 0.15. In ApoE-/- mice fed a high-fat diet for 12 weeks, treatment with rapamycin (1 mg/kg twice weekly for 4 weeks) reduced…
The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic…The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic signaling in aging female mice.
