Sphingosine has been studied in 1 paper since 2016: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Oct 14, 2026: “Biological modification of decellularized human umbilical artery with adipose stem cells and sphingosine-1-phosphate for development of thromboresistant small caliber vascular graft”.
Studies of Sphingosine measured 2 outcomes; the most studied are damaged lysosomes (1 study) and KCNN4EXPRESSION (1).
Damaged lysosomes
upin worms1
Sphingosine increases damaged lysosomes in worms.
“sphingosine supplementation leads to the appearance of damaged lysosomes in wild-type worms.”
Model organismswild-type worms
Molecular biology of the cell
KCNN4EXPRESSION
upin mouse cells1
Sphingosine increases KCNN4EXPRESSION in mouse cells.
“exogenous application of sphingosine or sphingosine 1-phosphate induced similar changes in levels of the antioxidant enzymes and upregulated KCa 3.1.”
Cellsprimary mouse aortic endothelial cells
Aging cell
In an experiment in mice with ovaries removed and fed a high-fat diet, the drug also reduced fat in bone marrow.In an experiment in mice with ovaries removed and fed a high-fat diet, the drug also reduced fat in bone marrow.