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KCNN4EXPRESSION

Gene

1 paper studies it3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Ministry of Education, Science and Technology and 1 more
  • Animals1

Interventions

1

Sphingosine

upin mouse cells1

1 study

  1. Sphingosine increases KCNN4EXPRESSION in mouse cells.

    “exogenous application of sphingosine or sphingosine 1-phosphate induced similar changes in levels of the antioxidant enzymes and upregulated KCa 3.1.”

    Cellsprimary mouse aortic endothelial cells

    KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress

    Aging cell

More on Sphingosine

Upstream

2

CERS5

upin mouse cells1

1 study

  1. CERS5 increases KCNN4EXPRESSION in mouse cells.

    “CerS5 transfection or exogenous application of sphingosine or sphingosine 1-phosphate induced similar changes in levels of the antioxidant enzymes and upregulated KCa 3.1.”

    Cellsshown by CerS5 transfectionprimary mouse aortic endothelial cells

    KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress

    Aging cell

More on CERS5

Sphingosine-1-phosphate

upin mouse cells1

1 study

  1. Sphingosine-1-phosphate increases KCNN4EXPRESSION in mouse cells.

    “exogenous application of sphingosine or sphingosine 1-phosphate induced similar changes in levels of the antioxidant enzymes and upregulated KCa 3.1.”

    Cellsprimary mouse aortic endothelial cells

    KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress

    Aging cell

More on Sphingosine-1-phosphate

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