Raloxifene

Intervention3 papers3 findingsPubChem 5035ChEBI 8772

Animals2

Outcomes

3

GFAP

downin mice1Very low certainty

1 study

Raloxifene prevents GFAP in mice.
Animalsin MPTP-lesioned OVX micestriatum10 daysfemales
Raloxifene and progesterone neuroprotection in a female mouse model of Parkinson's disease · Frontiers in neuroscience · 9 Sep 2026

Dopamine loss

downin mice1Very low certainty

1 study

Raloxifene prevents dopamine loss in mice.
Animalsin OVX MPTP-lesioned female micestriatum2.5 mg/kg, b.i.d.10 daysfemales
Raloxifene and progesterone neuroprotection in a female mouse model of Parkinson's disease · Frontiers in neuroscience · 9 Sep 2026

Dopamine loss →

Prostate weight

downin rats1Very low certainty

1 study

Raloxifene decreases prostate weight in rats.
Animalsin orchiectomized ratsmales
Improvement of Bone Healing by Combined Treatment with Selective Androgen and Estrogen Receptor Modulators in Female and Male Rats · Calcified tissue international · 25 Aug 2026

Latest

3

Frontiers in NeuroscienceAnimals24 Sep

Raloxifene and progesterone neuroprotection in a female mouse model of Parkinson's disease

Parkinson's disease

Tissue & CellReview28 Aug

Estrogen signaling and ferroptosis in intervertebral disc degeneration: A proposed mechanistic framework and its evidence gaps

Calcified Tissue InternationalAnimals25 Aug

Improvement of Bone Healing by Combined Treatment with Selective Androgen and Estrogen Receptor Modulators in Female and Male Rats

Bones and joints

ENDO 2025 AbstractResearch23 Oct

SAT-783 83y Old Woman On Long-Term Hormone Replacement Therapy (HRT) for Osteoporosis (OP) Management: n of 1, Revisiting the Role of HRT in OP Management

ENDO 2025 AbstractResearch23 Oct

SAT-782 Raloxifene as a Bridging Therapy for Low Bone Density in a Young Non-Binary Individual

ENDO 2025 AbstractHumans23 Oct

OR10-06 Mortality and Hospitalization Outcomes in Patients Aged 80 and Older Receiving Osteoporosis Treatment After Fracture