Losartan

1. Losartan has no effect on mitochondrion in mice.

   “At 33 months, there were no significant changes in any protein groups of losartan-treated mice.”

   Animalsvery old mice

   AGE AND LOSARTAN EFFECTS ON MITOCHONDRIAL PROTEOME IN MICE · GSA 2024 abstract · 31 Dec 2024

1. Losartan decreases protein folding and chaperones in mice.

   “In contrast, chaperone and muscle contraction proteins were downregulated.”

   Animalsaged mice

   AGE AND LOSARTAN EFFECTS ON MITOCHONDRIAL PROTEOME IN MICE · GSA 2024 abstract · 31 Dec 2024

Protein folding and chaperones →

1. Losartan increases fatty acid β-oxidation in mice.

   “Losartan treatment in 24-month-old mice upregulated the TCA cycle and beta-oxidation proteins.”

   Animalsaged mice

   AGE AND LOSARTAN EFFECTS ON MITOCHONDRIAL PROTEOME IN MICE · GSA 2024 abstract · 31 Dec 2024

Fatty acid β-oxidation →

1. Losartan improves lifespan in mice.

   “Losartan’s “rejuvenating” effect on serum and heart metabolome was associated with improved survival in WT mice (log-rank, p =0.015)”

   AnimalsWT mice

   LOSARTAN REJUVENATES SERUM AND HEART METABOLOME OF AGED MICE BY ANGIOTENSIN DEPENDENT AND INDEPENDENT MECHANISMS · GSA 2024 abstract · 31 Dec 2024

1. Losartan decreases metabolomic aging signature in mice (ρ=-0.22).

   “Aged mice treated with losartan displayed a global shift towards a more “youthful” serum metabolome (ρ=-0.22, p=0.01)”

   Animalsaged miceserum

   LOSARTAN REJUVENATES SERUM AND HEART METABOLOME OF AGED MICE BY ANGIOTENSIN DEPENDENT AND INDEPENDENT MECHANISMS · GSA 2024 abstract · 31 Dec 2024

Metabolomic aging signature →