Incident all-cause dementia

Disease

2 papers2 findings

  • Humans1

Associations

2

Angiotensin receptor blockers

downin humans1HR 0.86

1 study
  1. Angiotensin receptor blockers are associated with incident all-cause dementia in humans (HR 0.86, 95% CI 0.85–0.87).

    “Pooled ARBs were associated with lower dementia risk than lisinopril (HR, 0.86; 95% CI, 0.85 to 0.87)”

    HumansACEI/ARB-naive adults initiating treatment; compared with lisinoprilMedian follow-up of 4.7 to 7.2 years

    Related blood pressure drugs linked to differing dementia risks

    medRxiv14 Oct 2026Preprint

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Periodontal disease

upin humans1

1 study
  1. Periodontal disease is associated with incident all-cause dementia in humans (Pooled HR ≈ 1.12; 95% CI 1.01–1.24).

    “a modest but statistically significant association between periodontal disease and incident all-cause dementia (pooled HR ≈ 1.12; 95% confidence interval, 1.01-1.24).”

    ReviewLongitudinal studies assessing periodontal disease before cognitive outcomes

    Periodontal disease and risk of dementia: a systematic review and meta-analysis

    Evidence-based dentistry6 Oct 2026

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Latest

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medRxiv

Related blood pressure drugs linked to differing dementia risks

Compared with lisinopril, the drugs collectively had a dementia hazard ratio of 0.86, indicating a lower rate of new diagnoses over follow-up.Compared with lisinopril, the drugs collectively had a dementia hazard ratio of 0.86, indicating a lower rate of new diagnoses over follow-up.

Preprint: cohort study of adults starting ARBs or lisinopril, against people starting lisinoprilVascular dementia

Limit: Dementia diagnoses drawn from health records and claims may miss undiagnosed cases

European Archives of Psychiatry and Clinical Neuroscience

Fine particle air pollution linked to higher dementia risk

In a prospective cohort followed for a median 11.9 years, 5,648 dementia cases were linked to particle pollution from domestic, transport and industrial sources.In a prospective cohort followed for a median 11.9 years, 5,648 dementia cases were linked to particle pollution from domestic, transport and industrial sources.

Cohort study of 5,648 peopleDementia
Drug Design, Development and Therapy

GLP-1 agonists linked to lower dementia risk after COVID-19

GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19 survivors.GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19 survivors.

Cohort study of 25,263 peopleGLP-1 receptor agonists