Serum metabolome aging signature

1. Losartan decreases serum metabolome aging signature in humans.

   “a phase 2 randomized placebo-controlled trial of losartan, which indicated a dose-dependent metabolic rejuvenation effect.”

   Human trialpre-frail; phase 2 randomized placebo-controlled trialserummales

   Multi-Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre-Frail Older Men by Losartan

   Aging cell·22 Apr 2026

2. Losartan decreases serum metabolome aging signature in mice.

   “Losartan treatment resulted in a shift in serum metabolome aging signature to a more youthful state.”

   Animalsserummales

   Multi-Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre-Frail Older Men by Losartan

   Aging cell·22 Apr 2026

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