Frailty score
Biomarker1 paper
- Humans1
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8Metabolic signature links frailty to coronary artery disease
A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year…A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year follow-up.
Electronic frailty index predicts CAR-T outcomes in older adults
Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.
CT biomarkers improve postoperative mortality prediction
Adding automated CT biomarkers to an ICD-based frailty score raised one-year mortality prediction AUROC from 0.75 to 0.79 in 7,638 surgery patients.Adding automated CT biomarkers to an ICD-based frailty score raised one-year mortality prediction AUROC from 0.75 to 0.79 in 7,638 surgery patients.
High metabolic inflammation trajectories predict faster frailty progression in older adults
Tracking the combined C-reactive protein-triglyceride-glucose index over time identified older adults at greater risk of incident frailty in two…Tracking the combined C-reactive protein-triglyceride-glucose index over time identified older adults at greater risk of incident frailty in two national cohorts.
Frailty links to lower thrombolysis use and male stroke deaths
Compared to low-frailty peers, highly frail stroke patients had adjusted risk ratios for thrombolysis of 0.66 in females and 0.72 in males.Compared to low-frailty peers, highly frail stroke patients had adjusted risk ratios for thrombolysis of 0.66 in females and 0.72 in males.