LOSARTAN REJUVENATES SERUM AND HEART METABOLOME OF AGED MICE BY ANGIOTENSIN DEPENDENT AND INDEPENDENT MECHANISMS

Abstract

Emerging evidence suggests losartan, a selective angiotensin II receptor type 1 (AT1) antagonist, may reduce frailty risk and improve physical function in older adults. Losartan is metabolized to EXP3174 (a potent AT1 antagonist) and EXP3179 (a PPARγ agonist).