Fucoidan

1. Fucoidan decreases LINE1 derepression in human cells.

   “pharmacological activation of SIRT6 using fucoidan from Fucus vesiculosus (Fucoidan-FV) partially attenuated aging-associated molecular defects, including genome instability and LINE1 derepression”

   Cellsin progeria fibroblasts

   Centenarian SIRT6 variants elevate SIRT6 protein and enhance cellular senescence resistance

   Research square·19 Jun 2026Preprint

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1. Fucoidan inhibits senescence-associated secretory phenotype (SASP) in human cells.

   “Fucoidan decreased p21 expression and inhibited SASP release without inducing cell death”

   Cellsin hyperoxia (50% O2)-exposed fASM cells100 μg/mL

   Targeting Hyperoxia-Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants

   Aging cell·1 May 2026

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1. Fucoidan decreases CDKN1A in human cells.

   “Fucoidan decreased p21 expression and inhibited SASP release without inducing cell death”

   Cellsin hyperoxia (50% O2)-exposed fASM cells100 μg/mL

   Targeting Hyperoxia-Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants

   Aging cell·1 May 2026

More on CDKN1A