EPIGALLOCATECHIN-3-GALLATE

1. EPIGALLOCATECHIN-3-GALLATE inhibits DNA methylation.

   “epigallocatechin-3-gallate, resveratrol, quercetin, genistein, and sulforaphane have been shown in preclinical studies to inhibit DNA methyltransferases”

   Reviewpreclinical studies

   The nutrigenomic-epigenetic axis in cancer: from dietary bioactives to precision oncology

   Nutrition & metabolism·15 Jun 2026

More on DNA methylation

1. EPIGALLOCATECHIN-3-GALLATE improves cognitive function in rats.

   “pre-anesthetic administration of EGCG modulated microglial phenotype differentiation, reduced neuronal damage, and improved postoperative cognitive function in aged rats following general anesthesia.”

   Animalsfollowing general anesthesia with isoflurane7 daysmales

   Preventive Effect of Epigallocatechin-3-Gallate on Postoperative Cognitive Dysfunction in Aged Rats via Modulation of Microglial Differentiation: An Experimental Animal Study

   International journal of molecular sciences·23 Nov 2025

1. EPIGALLOCATECHIN-3-GALLATE increases M2 microglia activation in rats (17.61 ± 5.52% vs. 5.99 ± 2.46% (p < 0.001)).

   “M2 phenotype activation was significantly higher (17.61 ± 5.52% vs. 5.99 ± 2.46%, p < 0.001) in the EGCG group than in the control group.”

   Animalsfollowing general anesthesia with isoflurane7 daysmales

   Preventive Effect of Epigallocatechin-3-Gallate on Postoperative Cognitive Dysfunction in Aged Rats via Modulation of Microglial Differentiation: An Experimental Animal Study

   International journal of molecular sciences·23 Nov 2025

More on M2 microglia activation

1. EPIGALLOCATECHIN-3-GALLATE decreases M1 microglia activation in rats (30.03 ± 7.73% vs. 51.00 ± 9.83% (p < 0.001)).

   “M1 phenotype activation was significantly lower (30.03 ± 7.73% vs. 51.00 ± 9.83%, p < 0.001)”

   Animalsfollowing general anesthesia with isoflurane7 daysmales

   Preventive Effect of Epigallocatechin-3-Gallate on Postoperative Cognitive Dysfunction in Aged Rats via Modulation of Microglial Differentiation: An Experimental Animal Study

   International journal of molecular sciences·23 Nov 2025

More on M1 microglia activation

1. EPIGALLOCATECHIN-3-GALLATE decreases neuronal damage in rats.

   “The EGCG group exhibited reduced neuronal damage and microglial activation.”

   Animalsfollowing general anesthesia with isoflurane7 daysmales

   Preventive Effect of Epigallocatechin-3-Gallate on Postoperative Cognitive Dysfunction in Aged Rats via Modulation of Microglial Differentiation: An Experimental Animal Study

   International journal of molecular sciences·23 Nov 2025

1. EPIGALLOCATECHIN-3-GALLATE increases alternation ratio in rats (70.00 ± 7.98% vs. 28.14 ± 11.52% (p < 0.001)).

   “At 24 h after anesthesia, the alternation ratio was significantly higher in the EGCG group than in the control group (70.00 ± 7.98% vs. 28.14 ± 11.52%, p < 0.001).”

   Animalspostoperative cognitive dysfunction following isoflurane general anesthesia7 daysmales

   Preventive Effect of Epigallocatechin-3-Gallate on Postoperative Cognitive Dysfunction in Aged Rats via Modulation of Microglial Differentiation: An Experimental Animal Study

   International journal of molecular sciences·23 Nov 2025

More on Alternation ratio