Carnitine

  • 1 lab in 1 country
  • Funders: National Institute of Allergy and Infectious Diseases and 3 more
  • Animals2

Outcomes

1

Transcriptional markers of CR

upin mice1

1 study
  1. Carnitine improves transcriptional markers of CR in mice.

    “Pioglitazone, a PPAR-γ agonist, and L-carnitine, an amino acid involved in lipid metabolism, displayed the strongest effects on both the novel transcriptional markers of CR and the additional CR biomarkers tested.”

    Animals3 months

    Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics

    Aging cellMay 26, 2017

More on Transcriptional markers of CR

Funding

1 grant since 2023

Japan Society for the Promotion of ScienceJP¥4.8m

Latest

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Clinical Nutrition

Lysine breakdown linked to limb lean mass in humans

In 40 postmenopausal women, blood and muscle measurements suggested distinct changes rather than a uniform shift across the lysine breakdown pathway.In 40 postmenopausal women, blood and muscle measurements suggested distinct changes rather than a uniform shift across the lysine breakdown pathway.

Mendelian randomizationMechanisms
Molecular & Cellular Proteomics

Cell-derived particles improved heart function in some aged mice

Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.

Mouse studyInterventions
Scientific Reports

Blood metabolites linked to heart failure in Finnish men

A cohort study of 10,115 Finnish men linked 45 blood metabolites to later heart failure, including 33 newly identified associations.A cohort study of 10,115 Finnish men linked 45 blood metabolites to later heart failure, including 33 newly identified associations.

Cohort · 10,115 peopleHeart failure
eLife

Periodic red light exposure eases cellular aging in mice

In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.

Experiments in miceInterventions