PDK4
Gene1 paper1 findingHGNC 8812MGI 1351481NCBI Gene 5166Taxon 9606
- Animals1
Effects
1Age-related pathologies
downin mice1
1 study
Age-related pathologies
downin mice1
PDK4 decreases age-related pathologies in mice.
“Pharmacological inhibition of PDK4 in vivo effectively ameliorates the age-related pathologies induced by hepatocyte-specific GHR ablation.”
Animalsin hepatocyte-specific GHR knockout miceliver
Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026
Latest
1Aging CellAnimals
Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice
The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.