GHR
Gene1 paper2 findingsHGNC 4263MGI 95708NCBI Gene 2690Taxon 9606
- Animals1
Effects
2Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
GHR prevents cellular senescence in mice.
“enhanced cellular senescence”
Animalshepatocyte-specific knockout
Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026
Lifespan
downin mice1
1 study
Lifespan
downin mice1
GHR shortens lifespan in mice.
“shortened lifespan”
Animalshepatocyte-specific knockout
Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026
Latest
1Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice
The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.