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MIR-34A

There are 11 papers on MIR-34A in aging research: 3 observational studies in people, 8 in animals.

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11 papers study it27 findings

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See all 11 papers on MIR-34A

At a glance

The findings reach people, from one lab or study; independent labs found the same change in cells. 11 independent labs in 5 countries.

“High miR-34a was independently associated with the presence of CAD”
Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosisAtherosclerosis2021doi:10.1016/j.atherosclerosis.2021.05.005

None of its findings points the other way.

Cells: replicated by independent labs. Mice and humans: a single group. Worms or flies: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 11 independent labs in 5 countries
  • Funders: National Institutes of Health and others
  • 1 of 27 findings with company ties
  • Humans3
  • Animals8

Interventions

4

Angiotensin II

upin human cells1

1 study

  1. Angiotensin II increases MIR-34A in HASMC.

    “Ang II enhances miR-34a in old rat VSMC and human aortic smooth muscle cells (HASMC)”

    Cellsin HASMCvascular smooth muscle cells

    Angiotensin II, miR-34a, and AGTRAP crosstalk in arterial smooth muscle cells

    GeroScience

More on Angiotensin II

High-fat diet

upin mice1

1 study

  1. High-fat diet increases MIR-34A in mice.

    “miR-34a is significantly upregulated in the liver tissues of the HFD mice and in the PA-treated BNL CL.2 cells.”

    Animalsliver

    Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6

    Molecular nutrition & food research

More on High-fat diet

Myostatin

upin mouse cells1

1 study

  1. Myostatin increases MIR-34A in mouse cells (treatment of C2C12 myoblasts).

    “Mstn treatment upregulated miR-34a in C2C12 myoblasts”

    Cellstreatment of C2C12 myoblasts

    MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle

    Journal of cellular biochemistry

More on Myostatin

Kallistatin

downin cells1

1 study

  1. Kallistatin decreases MIR-34A in cells (via its active site).

    “Kallistatin via its active site inhibited miR-34a, and stimulated SIRT1 and eNOS synthesis in EPCs”

    Cellsvia its active site

    Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway

    Aging cell

More on Kallistatin

Effects

14

Cellular senescence

upin cells1mediatesin human cells1upin human cells1upin mice1

4 studies

  1. MIR-34A mediates cellular senescence in human cells (shown by miR-34a antagomir blocking of EV-induced senescence markers).

    “increased expression of markers of senescence, such as p21CIP1 and positive staining for senescence-associated β-galactosidase, which were blocked by a specific miR-34a antagomir”

    Cellsshown by miR-34a antagomir blocking of EV-induced senescence markers

    Chronic Obstructive Pulmonary Disease Airway Epithelial Cell-derived Extracellular Vesicles Spread Cellular Senescence via MicroRNA-34a

    American journal of respiratory cell and molecular biology

  2. MIR-34A induces cellular senescence in mice (by targeting CDK6).

    “miR-34a is upregulated in a high-fat environment in the liver, and induces hepatocyte senescence by targeting CDK6.”

    Animalsby targeting CDK6liver

    Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6

    Molecular nutrition & food research

  3. MIR-34A increases cellular senescence in human cells (shown by overexpression).

    “But, miR-34a promotes hepatocyte senescence and apoptosis.”

    Cellsshown by overexpression

    Alcohol-mediated miR-34a modulates hepatocyte growth and apoptosis

    Journal of cellular and molecular medicine

  4. MIR-34A induces cellular senescence in lung fibroblasts.

    “miR-34a induced a senescent phenotype in lung fibroblasts”

    Cellsin lung fibroblastslung

    miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence

    American journal of respiratory cell and molecular biology

More on Cellular senescence

AGTRAP

downin human cells1

1 study

  1. MIR-34A decreases AGTRAP in human cells (miR-34a overexpression in HASMC).

    “miR-34a directly targets AGTRAP”

    CellsmiR-34a overexpression in HASMCvascular smooth muscle cells

    Angiotensin II, miR-34a, and AGTRAP crosstalk in arterial smooth muscle cells

    GeroScience

More on AGTRAP

CDK6

downin mouse cells1

1 study

  1. MIR-34A inhibits CDK6 in mouse cells.

    “CDK6 is a target of miR-34a, which binds to the 3' UTR of CDK6 and inhibits its expression.”

    Cells

    Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6

    Molecular nutrition & food research

More on CDK6

Ceramide

upin mouse cells1

1 study

  1. MIR-34A increases ceramide in mouse cells (via targeting of CERK).

    “miR-34a targets CERK resulting in ceramide accumulation, activation of PP2A and the pJNK pathway in muscle and C2C12 myoblasts.”

    Cellsvia targeting of CERKskeletal muscle

    MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle

    Journal of cellular biochemistry

More on Ceramide

Insulin/IGF-1 signaling

downin mouse cells1

1 study

  1. MIR-34A impairs insulin/IGF-1 signaling in mouse cells (overexpression in C2C12 myoblasts; rescued by miR-34a antagonism).

    “Overexpression of miR-34a in C2C12 myoblasts leads to alterations in the insulin signaling pathway, which were rescued by its antagonism.”

    Cellsoverexpression in C2C12 myoblasts; rescued by miR-34a antagonism

    MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle

    Journal of cellular biochemistry

More on Insulin/IGF-1 signaling

Age-related hearing loss

upin mice1

1 study

  1. MIR-34A increases age-related hearing loss in mice (miR-34a deficiency).

    “Moreover, SIRT1 overexpression or miR-34a deficiency both attenuated age-related cochlear hair cell loss and hearing loss in C57BL/6 mice.”

    AnimalsmiR-34a deficiencycochlea

    Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis

    Neurobiology of aging

More on Age-related hearing loss

Expression in skeletal muscle and serum-derived extracellular vesicles

upin mice1

1 study

  1. MIR-34A increases expression in skeletal muscle and serum-derived extracellular vesicles in mice with age.

    “Aging in male and female C57BL6 mice was associated with a significant increase in expression of the senescence-associated microRNA miR-34a-5p (miR-34a) in skeletal muscle and in serum -derived EVs”

    Animalswith ageskeletal musclemale and females

    Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

    Aging

More on Expression in skeletal muscle and serum-derived extracellular vesicles

Apoptosis

upin human cells1

1 study

  1. MIR-34A increases apoptosis in human cells (shown by overexpression).

    “But, miR-34a promotes hepatocyte senescence and apoptosis.”

    Cellsshown by overexpression

    Alcohol-mediated miR-34a modulates hepatocyte growth and apoptosis

    Journal of cellular and molecular medicine

More on Apoptosis

Cell cycle regulation

downin human cells1

1 study

  1. MIR-34A decreases cell cycle regulation in human cells (shown by overexpression).

    “Overexpression of miR-34a in human hepatocytes suppressed cell growth signallings, including c-Met, cyclin D1 and cyclin-dependent kinase 6 (CDK6).”

    Cellsshown by overexpression

    Alcohol-mediated miR-34a modulates hepatocyte growth and apoptosis

    Journal of cellular and molecular medicine

More on Cell cycle regulation

Cell proliferative capacity

downin cells1

1 study

  1. MIR-34A decreases cell proliferative capacity in lung fibroblasts.

    “this microRNA increased senescence-associated β-galactosidase activity, enhanced expression of senescence markers, and decreased cell proliferative capacities”

    Cellsin lung fibroblastslung

    miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence

    American journal of respiratory cell and molecular biology

All 14

Associations

6

Arterial aging

upin rhesus monkeys1

1 study

  1. MIR-34A is associated with arterial aging in rhesus monkeys with age.

    “miR-34a exhibits an age-associated increase in Rhesus monkey's common carotid artery and rat aorta”

    Animalswith agecommon carotid artery

    Angiotensin II, miR-34a, and AGTRAP crosstalk in arterial smooth muscle cells

    GeroScience

SIRT1

downin humans1

1 study

  1. MIR-34A is associated with SIRT1 in humans.

    “the increased levels of miR-34a or miR-34c were inversely associated with expression of SIRT1 or JAG1, NOTCH2, CTNNB1 and ATF1, respectively”

    Humansperipheral blood mononuclear cells

    Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis

    Atherosclerosis

More on SIRT1

Coronary artery disease

upin humans1OR 3.87

1 study

  1. MIR-34A is associated with coronary artery disease in humans (independent association after confounder adjustment) (OR 3.87 (95% CI 1.56-9.56); p = 0.003).

    “High miR-34a was independently associated with the presence of CAD”

    Humansindependent association after confounder adjustmentperipheral blood mononuclear cells

    Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis

    Atherosclerosis

More on Coronary artery disease

Insulin resistance

upin human cells1

1 study

  1. MIR-34A is associated with insulin resistance in human cells (myoblasts from insulin resistant humans).

    “miR-34a is elevated in the muscles of 2-year-old mice and in the myoblasts of IR humans”

    Cellsmyoblasts from insulin resistant humans

    MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle

    Journal of cellular biochemistry

More on Insulin resistance

Aged skeletal muscle

upin mice1

1 study

  1. MIR-34A is associated with aged skeletal muscle in mice (2-year-old mice).

    “miR-34a is elevated in the muscles of 2-year-old mice and in the myoblasts of IR humans”

    Animals2-year-old miceskeletal muscle

    MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle

    Journal of cellular biochemistry

Idiopathic pulmonary fibrosis

upin humans1

1 study

  1. MIR-34A is associated with idiopathic pulmonary fibrosis in humans.

    “miR-34a demonstrated greater expression in the lungs of patients with idiopathic pulmonary fibrosis”

    Humanslung

    miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence

    American journal of respiratory cell and molecular biology

More on Idiopathic pulmonary fibrosis

Latest

See all 11 papers on MIR-34A

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