Kallistatin
Kallistatin has been studied in 3 papers since 2017: none in people yet, 3 in animals. The research so far is in animals. The newest paper, Dec 2, 2018: “Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation”.
See all 3 papers on kallistatin
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Anatomical Society and 1 more
- Animals3
What did studies of kallistatin find?
6Studies of kallistatin measured 6 outcomes; the most studied are cellular senescence (3 studies), lifespan (2) and oxidative stress and ROS signaling (1).
Cellular senescence
downin mice2downin cells1downin humans1
3 studies
Cellular senescence
downin mice2downin cells1downin humans1
Kallistatin decreases cellular senescence in humans (oxidative stress-induced senescence in human endothelial cells).
“Kallistatin inhibits oxidative stress-induced cellular senescence by upregulating Let-7g synthesis”
Reviewoxidative stress-induced senescence in human endothelial cellsendothelial cell
Oxidative medicine and cellular longevity
Kallistatin decreases cellular senescence in mice (streptozotocin-induced diabetes; acting via miR-34a and miR-21 downregulation).
“By downregulating miR-34a and miR-21 expression, kallistatin treatment attenuates oxidative damage and aortic senescence in streptozotocin-induced diabetic mice”
Reviewstreptozotocin-induced diabetes; acting via miR-34a and miR-21 downregulationaorta
Role of Kallistatin Treatment in Aging and Cancer by Modulating miR-34a and miR-21 Expression
Oxidative medicine and cellular longevity
Kallistatin decreases cellular senescence in mice (streptozotocin-induced diabetic mice).
“kallistatin administration attenuated STZ-induced aortic senescence, oxidative stress, and miR-34a and miR-21 synthesis”
Animalsstreptozotocin-induced diabetic miceaorta
Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway
Aging cell
Kallistatin decreases cellular senescence in cells (TNF-α-induced senescence).
“Human kallistatin significantly decreased TNF-α-induced cellular senescence in EPCs”
CellsTNF-α-induced senescencehuman
Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway
Aging cell
Lifespan
upin worms2
2 studies
Lifespan
upin worms2
Kallistatin extends lifespan in worms under stress conditions.
“extends Caenorhabditis elegans lifespan under stress conditions”
Reviewunder stress conditions
Role of Kallistatin Treatment in Aging and Cancer by Modulating miR-34a and miR-21 Expression
Oxidative medicine and cellular longevity
Kallistatin extends lifespan in worms under oxidative or heat stress.
“kallistatin treatment reduced superoxide formation and prolonged wild-type C. elegans lifespan under oxidative or heat stress”
Model organismsunder oxidative or heat stress
Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway
Aging cell
Oxidative stress and ROS signaling
downin reviews1
1 study
Oxidative stress and ROS signaling
downin reviews1
Kallistatin decreases oxidative stress and ROS signaling (endogenous kallistatin).
“endogenous kallistatin displays a novel role in protection against vascular injury and senescence by inhibiting oxidative stress and inflammation”
Reviewendogenous kallistatin
Oxidative medicine and cellular longevity
Vascular injury
downin mice1
1 study
Vascular injury
downin mice1
Kallistatin decreases vascular injury in streptozotocin-induced diabetic mice.
“Exogenous kallistatin administration attenuates vascular injury and senescence in association with increased SIRT1 and eNOS levels”
Reviewin streptozotocin-induced diabetic miceexogenous administrationaorta
Oxidative medicine and cellular longevity
Apoptosis
upin reviews1
1 study
Apoptosis
upin reviews1
Kallistatin induces apoptosis (breast cancer cells).
“kallistatin's active site is essential for stimulating miR-34a and p53 expression and inhibiting the miR-21-Akt-Bcl-2 signaling pathway, thus inducing apoptosis in breast cancer cells”
Reviewbreast cancer cells
Role of Kallistatin Treatment in Aging and Cancer by Modulating miR-34a and miR-21 Expression
Oxidative medicine and cellular longevity
MIR-34A
downin cells1
1 study
MIR-34A
downin cells1
Kallistatin decreases MIR-34A in cells (via its active site).
“Kallistatin via its active site inhibited miR-34a, and stimulated SIRT1 and eNOS synthesis in EPCs”
Cellsvia its active site
Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway
Aging cell