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Myostatin

Myostatin has been studied in 11 papers since 2012: 1 observational study in people, 4 in animals, 1 in cells, 5 reviews. It has not reached trials in people. The newest paper, Nov 7, 2024: “Myokines and Their Potential Protective Role Against Oxidative Stress in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)”.

InterventionPreclinical

11 papers study it3 findingsUpdated

MeSH

See all 11 papers on myostatin

At a glance

The findings reach cells, none yet in people. 3 independent labs in 2 countries.

None of its findings points the other way.

Cells: a single group. Worms or flies, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 3 independent labs in 2 countries
  • Funders: Congressionally Directed Medical Research Programs and 6 more
  • Humans1
  • Animals4
  • Cells1

What did studies of myostatin find?

3

Studies of myostatin measured 3 outcomes; the most studied are muscle regeneration (1 study), MIR-34A (1) and bone marrow stromal cell proliferation (1).

Muscle regeneration

downin human cells1

1 study

  1. Myostatin inhibits muscle regeneration in myoblasts in vitro.

    “MSTN mature peptides inhibit muscle regeneration by inducing G2/M phase blockade in myoblasts”

    Cellsin myoblasts in vitromature peptide

    Precise resistance training alleviates osteosarcopenia via the GLP-1/myostatin path: a 32-week randomized controlled trial and molecular mechanism study

    Archives of physiology and biochemistry

MIR-34A

upin mouse cells1

1 study

  1. Myostatin increases MIR-34A in mouse cells (treatment of C2C12 myoblasts).

    “Mstn treatment upregulated miR-34a in C2C12 myoblasts”

    Cellstreatment of C2C12 myoblasts

    MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle

    Journal of cellular biochemistry

More on MIR-34A

Bone marrow stromal cell proliferation

downin mouse cells1

1 study

  1. Myostatin decreases bone marrow stromal cell proliferation in mouse cells (dose-dependent).

    “Myostatin reduced proliferation of both young and aged BMSCs in a dose-dependent fashion”

    Cellsbone marrow stromal cell

    Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells

    Experimental gerontology

Funding

2 grants since 2018

Wellcome TrustUKRI | Medical Research Council

Contains public sector information licensed under the Open Government Licence v3.0.

Latest

See all 11 papers on myostatin

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