MAPT
GeneHomo sapiens6 papers1 findingHGNC 6893NCBI Gene 4137Taxon 9606
- Model organisms1
- Cells4
Interventions
1Mtdna depletion
upin human cells1
1 study
Mtdna depletion
upin human cells1
Mtdna depletion increases MAPT in human cells.
Cellschronic mtDNA depletion (rho0)SH-SY5Y
Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels · Journal of Alzheimer's disease : JAD · 29 Sep 2026
Latest
13Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants
Model organismsPreprintbioRxiv : the preprint server for biology
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
bioRxiv · Alsolami S et al.
Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease
ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Differential proteostasis imbalance and the molecular basis of distinct synucleinopathies and tauopathies
ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Neuroinflammation and Autophagy in Neurodegeneration: Cellular Mechanisms and Therapeutic Strategies
ReviewCNS & neurological disorders drug targets
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies
ReviewFrontiers in molecular neuroscience
Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels
CellsJournal of Alzheimer's disease : JAD
Excess linear ubiquitination disrupts aggregate clearance and impairs proteostasis in cells
Inactivating the ligase HOIL-1 solidifies dynamic protein condensates and impairs the autophagic clearance of tau, amyloid-beta, and alpha-synuclein aggregates.
The EMBO journal · Kaypee S et al.