APP
GeneHomo sapiens4 papersHGNC 620NCBI Gene 351Taxon 9606
- Model organisms1
- Cells3
Latest
8Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants
Model organismsPreprintbioRxiv : the preprint server for biology
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
bioRxiv · Alsolami S et al.
Neuroinflammation and Autophagy in Neurodegeneration: Cellular Mechanisms and Therapeutic Strategies
ReviewCNS & neurological disorders drug targets
Excess linear ubiquitination disrupts aggregate clearance and impairs proteostasis in cells
Inactivating the ligase HOIL-1 solidifies dynamic protein condensates and impairs the autophagic clearance of tau, amyloid-beta, and alpha-synuclein aggregates.
The EMBO journal · Kaypee S et al.
Astrocytic BAG3 regulates protein clearance systems linked to Alzheimer disease
Loss of the chaperone mediator in human astrocytes disrupts autophagy, proteasomes, and retromer traffic while impairing amyloid-beta proteostasis in neuron cocultures.
Proceedings of the National Academy of Sciences of the United States of America · Augur ZM et al.
Mechanisms of Brain Aging and Their Links to Alzheimer's and Parkinson's Disease Pathology
ReviewInternational journal of molecular sciences
Blood biomarkers of oxidative stress and mitochondrial dysfunction in Parkinson's disease and Alzheimer's disease
ReviewInternational review of neurobiology