Scientific Reports
Protein loss altered kidney filter structure in mice
Mice engineered to lack a protein developed abnormal kidney-filter deposits, but the loss did not severely impair kidney function.Mice engineered to lack a protein developed abnormal kidney-filter deposits, but the loss did not severely impair kidney function.
Mouse studyKidney
Who was studiedMice lacking R3hdml, 18 months, against heterozygous control mice
What changedAged mice lacking R3hdml developed more hump-like deposits in kidney filters than heterozygous control mice
The catchDirect and indirect causes of mesangial expansion were not distinguished
