Spontaneous tumors
21 papers20 findings
- Animals20
Interventions
3Metformin
no changein mice1
1 study
Metformin
no changein mice1
Metformin has no effect on spontaneous tumors in mice.
“treatment with metformin failed influence spontaneous tumor incidence in male 129/Sv mice”
Animalsin drinking water100 mg/kgmales
Aging1 Dec 2010
Epithalone
downin rats1
1 study
Epithalone
downin rats1
Epithalone decreases spontaneous tumors in rats.
“Epithalone injected to rats exposed to any photoregimen significantly inhibited the development of spontaneous tumors”
Animalsunder any photoregimensubcutaneous injection, 5 times a week0.1 microg/ratuntil natural deathmales
Bulletin of experimental biology and medicine1 Apr 2008
Epithalon
downin rats1
1 study
Epithalon
downin rats1
Epithalon inhibits spontaneous tumors in rats.
“This peptide exhibited virtually no effect on the development of spontaneous tumors in rats exposed to standard and constant illumination, but significantly inhibited their development in rats exposed to natural light.”
Animalsin rats exposed to natural light0.1 microg daily 5 times a weekfemales
Bulletin of experimental biology and medicine1 Dec 2007
Upstream
3MAP3K8
no changein mice1
1 study
MAP3K8
no changein mice1
MAP3K8 has no effect on spontaneous tumors in mice.
“incidence and severity of spontaneous tumors and non-neoplastic lesions were comparable between wild type and Tpl2-KD mice”
Animalskinase-dead mutation
Tpl2 kinase regulates inflammation but not tumorigenesis in mice
Toxicology and applied pharmacology13 Mar 2021
NPY
downin mice1
1 study
NPY
downin mice1
NPY protects against spontaneous tumors in mice.
“as was the effect on the occurrence of spontaneous tumors and oxidative stress responses in comparison to wild-type mice”
Animalslifelong 30% DR in Npy-null vs wild-type mice
A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction
Scientific reports31 Mar 2014
SHC1
no changein mice1
1 study
SHC1
no changein mice1
SHC1 has no effect on spontaneous tumors in mice.
“Spontaneous tumor incidence was investigated and found unaltered in two different strains, 129Sv and C57Bl/6J, p66KO mice.”
Animalsin 129Sv and C57Bl/6J mice
Current pharmaceutical design1 Jan 2013
Associations
10Melatonin
upin mice2downin rats1
3 studies
Melatonin
upin mice2downin rats1
Melatonin lowers the risk of spontaneous tumors in rats.
“Melatonin also decreased spontaneous tumor development, first of all, mammary and uterine neoplasm, in the rats kept at the constant illumination.”
Animalsin rats kept at constant illuminationfemales
Advances in gerontology = Uspekhi gerontologii1 Jan 2007
Melatonin raises the risk of spontaneous tumors in mice.
“treatment with the used dose of melatonin increased spontaneous tumor incidence in mice.”
Animalsdrinking water20 mg/l5 consecutive days every monthfemales
Melatonin increases both life span and tumor incidence in female CBA mice
The journals of gerontology. Series A, Biological sciences and medical sciences1 Jul 2001
Melatonin raises the risk of spontaneous tumors in mice.
“Increase in life span led to higher spontaneous tumor incidence.”
Animalsuntil natural deathdrinking water20 mg/l5 consecutive days monthlyfemales
Voprosy onkologii1 Jan 2000
RBM38
upin mice1downin mice1
2 studies
RBM38
upin mice1downin mice1
RBM38 raises the risk of spontaneous tumors in mice.
“S193D KI mice have a shortened life span and are prone to spontaneous tumors, chronic inflammation, and liver steatosis”
AnimalsS193D knock-in
Genes & development4 Mar 2021
RBM38 lowers the risk of spontaneous tumors in mice.
“Rbm38 is necessary for normal hematopoiesis and for suppressing accelerated aging and tumorigenesis”
Animalsshown by knockout
Proceedings of the National Academy of Sciences of the United States of America15 Dec 2014
Constant illumination
upin rats2
2 studies
Constant illumination
upin rats2
Constant illumination raises the risk of spontaneous tumors in rats.
“Permanent illumination promoted the development of spontaneous tumors in comparison with the standard photoregimen.”
Animalsmales
Bulletin of experimental biology and medicine1 Apr 2008
Constant illumination raises the risk of spontaneous tumors in rats.
“and a significant increase in spontaneous tumor development rate as compared with standard lighting.”
Animalscompared with standard lightingfemales
Lighting effect on spontaneous tumor development in female rats
Voprosy onkologii1 Jan 2007
Voluntary running-wheel exercise
downin rats1
1 study
Voluntary running-wheel exercise
downin rats1
Voluntary running-wheel exercise lowers the risk of spontaneous tumors in rats (38% vs 54%).
“A larger percentage of animals in the SED group had tumors (54%), compared with EX rats (38%).”
Animalsvoluntary running-wheel exercise vs sedentary housingfemalesn = 108
Revisiting influences on tumor development focusing on laboratory housing
Journal of the American Association for Laboratory Animal Science : JAALAS1 May 2009
Light deprivation
downin rats1
1 study
Light deprivation
downin rats1
Light deprivation lowers the risk of spontaneous tumors in rats (2.1 times drop).
“Light deprivation resulted in a longer maximum life span and significant (2.1 times) drop in tumor incidence.”
Animalsfemales
Lighting effect on spontaneous tumor development in female rats
Voprosy onkologii1 Jan 2007
Natural lighting in the russian north-west
upin rats1
1 study
Natural lighting in the russian north-west
upin rats1
Natural lighting in the russian north-west raises the risk of spontaneous tumors in rats.
“and a significant increase in spontaneous tumor development rate as compared with standard lighting.”
Animalscompared with standard lightingfemales
Lighting effect on spontaneous tumor development in female rats
Voprosy onkologii1 Jan 2007
Neuronol
downin mice1
1 study
Neuronol
downin mice1
Neuronol lowers the risk of spontaneous tumors in mice.
“Neuronol inhibited the development of spontaneous tumors, primarily lymphomas”
Animalsfemales
Bulletin of experimental biology and medicine1 Dec 2003
Wistar mishima
upin rats1
1 study
Wistar mishima
upin rats1
Wistar mishima is associated with spontaneous tumors in rats (3.1% in males, 27.1% in females).
“Tumors were observed in 33 males (3.1%) and 246 females (27.1%).”
Animalsn = 1,960
Life span and spontaneous tumors incidence of the Wistar Mishima (WM/MsNrs) rat
Experimental animals1 Apr 2003
Lifespan
upin rats1
1 study
Lifespan
upin rats1
Spontaneous tumors are associated with lifespan in rats (p < 0.0001).
“The average life span of tumor-afflicted females was significantly longer than that of the non-tumor group (p < 0.0001)”
Animalsfemales
Life span and spontaneous tumors incidence of the Wistar Mishima (WM/MsNrs) rat
Experimental animals1 Apr 2003
Buformin
downin rats1
1 study
Buformin
downin rats1
Buformin lowers the risk of spontaneous tumors in rats.
“to reduce the incidence of spontaneous tumors.”
Animalsk mg/day per ratchronicfemales
Voprosy onkologii1 Jan 1980