Buformin
- 2 independent labs in 1 country
- Funders: Max-Planck-Institut für demografische Forschung and 1 more
- Animals2
Outcomes
4Mean life span of the last 10% survivors
upin rats1+12%
1 study
Mean life span of the last 10% survivors
upin rats1+12%
Buformin extends mean life span of the last 10% survivors in rats (+12%).
“The mean life span of the last 10% survivors increased by 12% (P < 0.05) and the maximum life span increased by 2 months (+5.5%) as compared with controls.”
Animalsfemales
Insulin and longevity: antidiabetic biguanides as geroprotectors
Biogerontology1 Jan 2003
Reproductive period
upin rats1
1 study
Reproductive period
upin rats1
Buformin increases reproductive period in rats.
“The treatment of rats with buformin and diphenylhydantoin was also found to prolong their reproductive period”
Animalsfemales
Voprosy onkologii1 Jan 1980
Body weight
downin rats1
1 study
Body weight
downin rats1
Buformin decreases body weight in rats.
“Chronic treatment of female rats with buformin (k mg/day per rat) is shown to decrease the body weight”
Animalsk mg/day per ratchronicfemales
Voprosy onkologii1 Jan 1980
Lifespan
upin rats1+9%
1 study
Lifespan
upin rats1+9%
Buformin extends lifespan in rats (+9%).
“Chronic treatment of female rats with buformin (k mg/day per rat) is shown to decrease the body weight, to increase the average life span by 9%”
Animalsk mg/day per ratchronicfemales
Voprosy onkologii1 Jan 1980
Associations
2Tumor incidence
downin rats1−50%
1 study
Tumor incidence
downin rats1−50%
Buformin lowers the risk of tumor incidence in rats (-49.5%).
“The total tumor incidence decreased by 49.5% in buformin-treated rats.”
Animalsfemales
Insulin and longevity: antidiabetic biguanides as geroprotectors
Biogerontology1 Jan 2003
Spontaneous tumors
downin rats1
1 study
Spontaneous tumors
downin rats1
Buformin lowers the risk of spontaneous tumors in rats.
“to reduce the incidence of spontaneous tumors.”
Animalsk mg/day per ratchronicfemales
Voprosy onkologii1 Jan 1980