Epithalon

1. Epithalon extends lifespan in rats (+95 days maximum lifespan).

   “while in rats exposed to the natural and constant light it promoted prolongation of the maximum life span by 95 and 24 days, respectively.”

   Animalsin rats exposed to natural light0.1 microg daily 5 times a weekfemales

   Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes

   Bulletin of experimental biology and medicine·1 Dec 2007

2. Epithalon has no effect on lifespan in rats.

   “Epithalon (0.1 microg daily 5 times a week from the age of 4 months) did not change the life span of rats living under conditions of standard day/night regimen”

   Animalsin rats exposed to standard day/night regimen0.1 microg daily 5 times a weekfemales

   Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes

   Bulletin of experimental biology and medicine·1 Dec 2007

3. Epithalon extends lifespan in mice.

   “prolonged the mice life span”

   Animalssynthetic tetrapeptideuntil deathfemales

   Effect of pineal peptide on parameters of the biological age and life span in mice

   Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·1 Jan 2001

1. Epithalon inhibits spontaneous tumors in rats.

   “This peptide exhibited virtually no effect on the development of spontaneous tumors in rats exposed to standard and constant illumination, but significantly inhibited their development in rats exposed to natural light.”

   Animalsin rats exposed to natural light0.1 microg daily 5 times a weekfemales

   Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes

   Bulletin of experimental biology and medicine·1 Dec 2007

More on Spontaneous tumors

1. Epithalon decreases oxidative stress and ROS signalling in mice.

   “decelerated free redical processes”

   Animalssynthetic tetrapeptideuntil deathfemales

   Effect of pineal peptide on parameters of the biological age and life span in mice

   Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·1 Jan 2001

More on Oxidative stress and ROS signalling

1. Epithalon decreases body temperature in mice.

   “decreased body temperature”

   Animalssynthetic tetrapeptideuntil deathfemales

   Effect of pineal peptide on parameters of the biological age and life span in mice

   Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·1 Jan 2001

More on Body temperature

1. Epithalon decreases age-related switching off of the estrus function in mice.

   “slowed down the age-related switching off of the estrus function”

   Animalssynthetic tetrapeptideuntil deathfemales

   Effect of pineal peptide on parameters of the biological age and life span in mice

   Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·1 Jan 2001

1. Epithalon lowers the risk of spontaneous tumour incidence in mice.

   “accompanying drop in spontaneous tumour incidence”

   Animalssynthetic tetrapeptideuntil deathfemales

   Effect of pineal peptide on parameters of the biological age and life span in mice

   Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·1 Jan 2001

More on Spontaneous tumour incidence