mtDNA heteroplasmy

1. Induced mesenchymal stem cell is associated with mtDNA heteroplasmy in human cells.

   “and a progressive reduction in heteroplasmic variants predicted to have pathogenic potential, including m.7913C>T and m.7821G>A”

   Cellscellular reprogramming into iPSCs and differentiation to iMSCs

   Characterization of the Mitochondrial Genome Landscape in MSCs, iPSCs and iMSCs from Osteoarthritis Patients and Healthy Donors · Genes · 11 Sep 2026

1. Osteoarthritis is associated with mtDNA heteroplasmy in human cells.

   “OA-derived MSCs exhibited a markedly increased heteroplasmic burden, followed by decrease in mtDNA copy number and accumulation of non-synonymous variants”

   Cellsbone marrow mesenchymal stem cell

   Characterization of the Mitochondrial Genome Landscape in MSCs, iPSCs and iMSCs from Osteoarthritis Patients and Healthy Donors · Genes · 11 Sep 2026

Osteoarthritis →