CDKN1A
GeneHomo sapiens9 papers2 findingsHGNC 1784NCBI Gene 1026Taxon 9606
- Humans1
- Animals2
- Cells6
Interventions
1Ormeloxifene
upin human cells1
1 study
Ormeloxifene
upin human cells1
Ormeloxifene increases CDKN1A in human cells.
CellsMCF-7
Ormeloxifene, a non-steroidal selective estrogen receptor modulator induces senescence in breast cancer cells · Molecular biology reports · 1 Oct 2026
Associations
1Osteoarthritis
downin silico1
1 study
Osteoarthritis
downin silico1
Osteoarthritis is associated with CDKN1A in silico (AUC 0.931).
“CDKN1A, CDK6, and WEE1 were reduced in OA-associated meniscal samples in GSE98918; within-dataset ROC analyses yielded AUCs of 0.931, 0.882, and 0.792, respectively.”
In silicomeniscus
Senescence-Associated Checkpoint Gene Dysregulation in Established Osteoarthritis: Integrated Transcriptomic Analysis and In Vitro Evaluation of CDK6 and WEE1 · Biomedicines · 26 Aug 2026
Latest
10DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
medRxiv · Simpson DJ et al.
Ormeloxifene, a non-steroidal selective estrogen receptor modulator induces senescence in breast cancer cells
Enhanced Extracellular Matrix Synthesis-Related Responses Induced by Ubiquinol-10 Derivatives in Human Dermal Fibroblasts
Heart Failure: Lipid Metabolism Disorders Driving Cellular Senescence Through a Vicious Cycle, and Possible Intervention Strategies
Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C
Loss of PP4 drives airway senescence through endoplasmic reticulum stress
Inhibiting the PERK pathway lowered cellular senescence and inflammatory markers in mouse models and cultured human airway cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] · Huang YT et al.
Aqueous Extract of Buddleja globosa Modulates Oxidative Stress-Induced Senescence-Associated Responses in THP-1-Derived Macrophages
CD47 blockade reduces doxorubicin-induced cardiac aging in male mice
Inhibiting CD47 lessens heart dysfunction and blunts cellular senescence caused by the chemotherapy drug doxorubicin.
Physiological reports · Yan A et al.