Cardiovascular risk

Disease

2 papers2 findings

  • Human trial1
  • Humans1

Associations

2

Hyperventilation-induced change in heart rate

downin humans1

1 study
  1. Cardiovascular risk is associated with hyperventilation-induced change in heart rate in humans (median 24.0 bpm to 15.0 bpm, p < 0.001).

    “ΔHR decreased monotonically across risk groups (Kruskal-Wallis H = 145.2, p < 0.001)”

    Humansmonotonic decrease across risk groupsn = 3,134

    Hyperventilation-Induced Heart Rate Response as a Marker of Cardiovascular Risk - Large-Scale Validation from the Courtois Cardiovascular Signature Program

    Research Square14 Oct 2026Preprint

More on Hyperventilation-induced change in heart rate

Systemic lipid metabolism subtype

upin humans1

1 study
  1. Systemic lipid metabolism subtype is associated with cardiovascular risk in humans.

    “systemic lipid metabolism was linked to elevated PCSK9 and higher cardiovascular risk”

    Humans

    Multi-omics dissection of MASLD reveals divergent pathways to systemic diseases and targets for prevention

    Metabolism: clinical and experimental11 Aug 2026

Trial sponsors

Funding

212 grants since 2016

National Heart, Lung, and Blood InstituteUS$59mAmerican Heart AssociationUS$9.8mCanadian Institutes of Health Research (CIHR) Project GrantCA$3.2m

Latest

Nov 2025: 191Dec 2025: 74Jan 2026: 41Feb 2026: 23Mar 2026: 24Apr 2026: 27May 2026: 26Jun 2026: 64Jul 2026: 84Aug 2026: 338Sep 2026: 293Oct 2026: 1441,329 in 12 months
Cardiovascular Diabetology

Blood marker rose before cardiovascular disease reports, then fell

Differences from controls were detectable 8 years before the first disease report in a matched observational study of 1,776 adults aged 50 or older.Differences from controls were detectable 8 years before the first disease report in a matched observational study of 1,776 adults aged 50 or older.

Cohort study of 1,776 adults aged ≥ 50 years without baseline CVD, against non-CVD controlsCardiovascular disease

Limit: Lipid- or glucose-lowering medications may explain part of the post-event decline