Hyperventilation-induced change in heart rate

1. Hyperventilation-induced change in heart rate predicts atherosclerotic cardiovascular disease in humans (AUC 0.659 [95% CI: 0.633–0.684]).

   “A logistic model incorporating age and ΔHR achieved an AUC of 0.659 [95% CI: 0.633–0.684]”

   Humanslogistic model incorporating age and ΔHRn = 3,134

   Hyperventilation-Induced Heart Rate Response as a Marker of Cardiovascular Risk - Large-Scale Validation from the Courtois Cardiovascular Signature Program

   Research Square·14 Oct 2026Preprint

More on Atherosclerotic cardiovascular disease

1. Cardiovascular risk is associated with hyperventilation-induced change in heart rate in humans (median 24.0 bpm to 15.0 bpm, p < 0.001).

   “ΔHR decreased monotonically across risk groups (Kruskal-Wallis H = 145.2, p < 0.001)”

   Humansmonotonic decrease across risk groupsn = 3,134

   Hyperventilation-Induced Heart Rate Response as a Marker of Cardiovascular Risk - Large-Scale Validation from the Courtois Cardiovascular Signature Program

   Research Square·14 Oct 2026Preprint

More on Cardiovascular risk