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Journal of Affective DisordersHumans

Persistent depression speeds frailty accumulation in older adults

Across 57,894 older adults, a persistent high depression burden predicted faster frailty accumulation at 1.42 × 10⁻³/year and elevated odds of…Across 57,894 older adults, a persistent high depression burden predicted faster frailty accumulation at 1.42 × 10⁻³/year and elevated odds of incident frailty.

Research SquareHumansPreprint

High depressive symptoms link to cardiometabolic multimorbidity

High-stable symptoms carried hazard ratios of 1.91 in Chinese adults and 1.59 in US adults for incident cardiometabolic multimorbidity compared with…High-stable symptoms carried hazard ratios of 1.91 in Chinese adults and 1.59 in US adults for incident cardiometabolic multimorbidity compared with low-stable symptoms.

European Journal of PainHumans

Multisite pain follows five trajectories in older Chinese adults

In 23,376 older adults tracked over nine years, trajectories ranged from persistent minimal pain in 44.9% to high increasing pain in 9.6%.In 23,376 older adults tracked over nine years, trajectories ranged from persistent minimal pain in 44.9% to high increasing pain in 9.6%.

Aging & Mental HealthHumans

Depression profiles link to cognitive and functional decline

In over 28,000 older adults, specific symptom configurations predicted lower cognition and higher daily living limitations four years later beyond…In over 28,000 older adults, specific symptom configurations predicted lower cognition and higher daily living limitations four years later beyond overall symptom severity.