Nuclear envelope
Cell component2 papersGO 0005635
- Animals1
- Cells1
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2bioRxivCellsPreprint
ApoD drives cellular aging phenotypes through a nuclear mechanotransduction feedback loop
In cultured fibroblasts and mice, apolipoprotein D triggers SUN1 accumulation, reinforcing a signaling cycle that alters gene expression and cellular…In cultured fibroblasts and mice, apolipoprotein D triggers SUN1 accumulation, reinforcing a signaling cycle that alters gene expression and cellular polarity.
Research SquareAnimalsPreprint
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice
The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung…The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung disease.