Telomere attrition

Biomarker

5 papers6 findings

  • Humans2
  • Animals1
  • Cells1

Upstream

3

Tuberculosis

upin reviews1

1 study
  1. Tuberculosis increases telomere attrition.

    “Chronic infections like HIV and tuberculosis exacerbate telomere attrition through sustained immune activation and oxidative stress.”

    Reviewin chronic infections like HIV and tuberculosis

    Global research landscape of telomere biology in infectious diseases: mechanistic links between host-pathogen interactions and immune ageing

    Frontiers in aging8 Jan 2026

More on Tuberculosis

HIV infection

upin reviews1

1 study
  1. HIV infection increases telomere attrition.

    “Chronic infections like HIV and tuberculosis exacerbate telomere attrition through sustained immune activation and oxidative stress.”

    Reviewin chronic infections like HIV and tuberculosis

    Global research landscape of telomere biology in infectious diseases: mechanistic links between host-pathogen interactions and immune ageing

    Frontiers in aging8 Jan 2026

More on HIV infection

ERCC6

downin human cells1

1 study
  1. ERCC6 prevents telomere attrition in human cells.

    “increased telomere attrition, senescent morphology, and early activation of senescence-associated β-galactosidase associated with increased DNA damage and aberrant DNA repair.”

    Cellsunder chronic oxidative exposure

    Protective role of Cockayne Syndrome B (CSB) protein in maintaining genome integrity in human cells under oxidative stress

    Mutation research. Genetic toxicology and environmental mutagenesis9 Sep 2025

More on ERCC6

Associations

3

Plumage darkening

downin H. rustica1

1 study
  1. Plumage darkening is associated with telomere attrition in H. rustica.

    “plumage darkening between consecutive years was associated with reduced ΔTL in both sexes”

    Animals

    Telomere Length at Recruitment Predicts Lifespan and Lifetime Reproductive Success in the Barn Swallow (Hirundo rustica)

    Molecular ecology1 Aug 2026

Gardening

downin humans1

1 study
  1. Gardening predicts telomere attrition in humans.

    “Longitudinally, more frequent gardening predicted slower declines in gait speed and telomere attrition from age 79 to 90.”

    HumansMore frequent gardeningblood

    Gardening, healthy aging, and longevity: Longitudinal evidence from 25 years of the Lothian Birth Cohort 1921

    Journal of environmental psychology18 Dec 2025

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Waist-to-hip ratio

upin humans1

1 study
  1. Waist-to-hip ratio is associated with telomere attrition in humans (p = 0.01).

    “Higher waist-to-hip ratio was associated with faster telomere attrition longitudinally (p = 0.01).”

    Humansleukocytemedian 6-year follow-upfemalesn = 958

    Genetic and environmental risk factors for major depression in UK women and their association with telomere length longitudinally

    Journal of affective disorders6 Dec 2025

More on Waist-to-hip ratio

Funding

2 grants since 2023

Veterans AffairsNational Institute on AgingUS$276.3k

Latest

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Research Square

Blood-cell telomerase delays premature aging in zebrafish

Boosting telomerase in blood-forming cells extended lifespan in immune-deficient zebrafish and partly restored gut health, operating without major changes in telomere…Boosting telomerase in blood-forming cells extended lifespan in immune-deficient zebrafish and partly restored gut health, operating without major changes in telomere length.

Preprint: experiments in zebrafishTelomerase and telomere maintenance