Resistance

1 paper

Humans1

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1,954 in 12 months

Research Square5 h

Brain scan markers may track different processes after sleep loss

In a 429-person sleep intervention study, proposed brain-scan measures of waste clearance responded differently to restricted sleep and prolonged wakefulness.In a 429-person sleep intervention study, proposed brain-scan measures of waste clearance responded differently to restricted sleep and prolonged wakefulness.

Preprint: non-randomised trial in 429 people exposed to short-term sleep loss, against habitual sleepMechanisms

Limit: MRI indices were indirect markers, not direct measurements of brain waste clearance

Paper

International Journal of Biological Macromolecules5 h

Pharmacological targeting of FKBPL with rapamycin sensitizes triple-negative breast cancer to ferroptosis

Experiments in cellsRapamycin

Paper

The Journal of Nutritional Biochemistry5 h

Metabolic Reprogramming by Time-Restricted Feeding Confers Resistance to PM2.5-Induced Metabolic Disturbances in Adipose Tissue

Experiments in miceDietary restriction

Paper

Cytokine & Growth Factor Reviews5 h

Immunosenescence in colorectal cancer: Interplay of microbiota, inflammaging, and metabolic reprogramming

ReviewMicrobiome composition

Paper

bioRxiv5 h

End-to-end genome map completed for the naked mole-rat

A genome-sequencing study resolved both inherited copies of the naked mole-rat genome, using gene-activity data from 23 tissues to identify its genes.A genome-sequencing study resolved both inherited copies of the naked mole-rat genome, using gene-activity data from 23 tissues to identify its genes.

Preprint: study of naked mole-ratsAI & data

Limit: Genome comparisons cannot determine gene changes’ effects on longevity or cancer resistance

Paper

Preprints.org5 h

NAD⁺/NADH as the Electrochemical Currency and Other Specific Electron Transfer Molecules in Health and Disease

Preprint: reviewMechanisms

Paper

Cell Death & Disease7 h

Lowering a protein reduced drug sensitivity in senescent cells

In laboratory experiments, reducing the protein weakened two drugs’ cell-killing effects without changing the usual signs of senescence, a state in which cells stop…In laboratory experiments, reducing the protein weakened two drugs’ cell-killing effects without changing the usual signs of senescence, a state in which cells stop dividing.

Experiments in senescent cells and aged miceCellular senescence

Limit: Drug doses were not reported, limiting interpretation of the reduced drug sensitivity

Paper

Journal of the American Heart AssociationYesterday

Dapagliflozin may help frail patients more after valve replacement

In frail patients, dapagliflozin was linked to lower relative risk of death or worsening heart failure versus controls at one year (hazard ratio 0.53).In frail patients, dapagliflozin was linked to lower relative risk of death or worsening heart failure versus controls at one year (hazard ratio 0.53).

Study of 1,222 patients undergoing transcatheter aortic valve implantation, against frail controlsDapagliflozin

Limit: Frailty subgroups were analysed after the fact, so the apparent extra benefit needs confirmation

Paper

JACC Case ReportsYesterday

Low-Frequency Whole-Body Vibration and Isometric Exercise in Cardiac Rehabilitation: Improved Capacity and Triglyceride-Glucose Index

Case reportCardiac rehabilitation

Paper

Preprints.orgYesterday

Stronger Through the Transition: Evaluating the Effect of Creatine and Resistance Training on Body Composition, Strength, and Sleep in Perimenopause

Preprint: randomised trial in 51 peopleCreatine

Paper

Resistance

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