Plasma proteins
Biomarker1 paper3 findings
A human cohort associates plasma proteins with incident acute myocardial infarction and shows improved 10-year prediction when proteins supplement clinical predictors. A human preprint also links plasma proteins to cancer risk.
- Humans1
Effects
110-year acute myocardial infarction prediction
upin humans1
1 study
10-year acute myocardial infarction prediction
upin humans1
Plasma proteins improve 10-year acute myocardial infarction prediction in humans (Harrell C 0.748 → 0.780; ΔC = 0.032, 95% CI 0.021–0.043).
HumansPlasma proteins added to clinical predictors in an elastic-net Cox modelplasma10-year prediction horizon
Blood protein links to heart attacks vary with kidney function · Kidney research and clinical practice · 6 Oct 2026
Associations
2Incident acute myocardial infarction
mixedin humans1
1 study
Incident acute myocardial infarction
mixedin humans1
Plasma proteins are associated with incident acute myocardial infarction in humans (975 proteins associated with AMI).
HumansAfter multivariable adjustmentplasmaMedian 13.9-year follow-upn = 29,417
Blood protein links to heart attacks vary with kidney function · Kidney research and clinical practice · 6 Oct 2026
Cancer risk
mixedin humans1
1 study
Cancer risk
mixedin humans1
Plasma proteins are associated with cancer risk in humans.
Humansacross 25 cancer endpoints in multivariable-adjusted models
Plasma proteomics reveals pre-diagnostic markers for 25 cancers · medRxiv : the preprint server for health sciences · 23 Sep 2026 · Preprint
Latest
9Blood protein links to heart attacks vary with kidney function
Links to heart attacks were stronger at lower kidney function for 154 blood proteins and at higher function for 22.Links to heart attacks were stronger at lower kidney function for 154 blood proteins and at higher function for 22.
Plasma proteomics reveals pre-diagnostic markers for 25 cancers
In a study of 9,828 participants, researchers identified 1,732 plasma protein associations across 25 cancers, with 49% statistically replicated in an…In a study of 9,828 participants, researchers identified 1,732 plasma protein associations across 25 cancers, with 49% statistically replicated in an independent cohort.
Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Organ age acceleration and mortality risk reflect distinct biological processes
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from…Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality.
Blood proteins improve early cardiometabolic risk prediction
In 43,709 adults with early-stage disease, outcome-specific proteomic signatures improved clinical risk discrimination across 11 incident outcomes…In 43,709 adults with early-stage disease, outcome-specific proteomic signatures improved clinical risk discrimination across 11 incident outcomes, boosting C-index values by 0.024 to 0.070.
Air pollutants link to disease through distinct proteomic paths
In 48,645 UK Biobank participants, plasma proteomic profiles linked ambient air pollutants to mortality and chronic diseases through shared immune and…In 48,645 UK Biobank participants, plasma proteomic profiles linked ambient air pollutants to mortality and chronic diseases through shared immune and divergent molecular pathways.
APOE disease risks and proteomic links vary by ancestry
A phenome-wide study of 367,757 All of Us participants linked APOE alleles to 27 phenotypes, finding ancestry-specific risks for dementia and fatty…A phenome-wide study of 367,757 All of Us participants linked APOE alleles to 27 phenotypes, finding ancestry-specific risks for dementia and fatty liver disease.
Plasma proteins link to metabolomic aging and disease risk
In over 400,000 UK Biobank participants, an NMR metabolomic aging score tracked mortality and pinpointed six candidate causal plasma proteins across…In over 400,000 UK Biobank participants, an NMR metabolomic aging score tracked mortality and pinpointed six candidate causal plasma proteins across adulthood.