Papers on NLRP3 inflammasome

541 papers40 new in 30 days

Wednesday, September 16

Frontiers in NutritionSep 16

Celery seed extract attenuates sarcopenic obesity and age-related sarcopenia by reducing intramuscular lipid accumulation in mice

Celery seed extract attenuates skeletal muscle loss and functional decline in obese and aged mice.

Experiments in miceSarcopenic obesity

Paper

Tuesday, September 15

NutrientsSep 15

Low-Grade Chronic Inflammation and Atherosclerotic Cardiovascular Risk: The Beneficial Role of Specific Nutritional Approaches

High-sensitivity C-reactive protein (hsCRP) and cardiovascular disease (CVD) risk.

ReviewAtherosclerotic cardiovascular disease

Paper

Sunday, September 13

Metabolic Brain DiseaseSep 13

Dihydromyricetin ameliorates cognitive dysfunction in SAMP8 mice via autophagy-mediated degradation of the NLRP3 inflammasome

Experiments in miceCognitive dysfunction

Paper

Tuesday, September 8

American Journal of TransplantationSep 8

NLR family pyrin domain containing 3-mediated Kupffer cell pyroptosis aggravates ischemia-reperfusion injury after aging donor liver transplantation through CD38-nicotinamide adenine dinucleotide⁺-sirtuin 1-dependent acetylation of estrogen-related receptor α

Figure from American Journal of Transplantation

Experiments in micePyroptosis

Paper

Thursday, September 3

Research SquareSep 3

RGS10 controls the metabolic and neuroinflammatory benefits of NLRP3 suppression in diet-induced obesity in male mice

Preprint: experiments in miceInflammation

Paper

Bone ResearchSep 3

Inhibition of ERK5 activity ameliorates osteoarthritis by suppressing NLRP3 inflammasome-mediated chondrocyte pyroptosis

Elevated p-ERK5 levels in human and mice OA cartilage.

Experiments in micePyroptosis

Paper

Tuesday, September 1

Journal of Inflammation ResearchSep 1

Spatial-Bioenergetic-Immune Axis in Type 2 Diabetes Mellitus-Associated Sarcopenia: A Review from Pathogenesis to Targeted Reconstruction

Spatial isolation and metabolic signaling disruption in T2DM-associated sarcopenia.

ReviewMuscle

Paper

Monday, August 31

Journal of the Formosan Medical AssociationAug 31

Clonal hematopoiesis and atherosclerotic cardiovascular disease: Clinical implications, biological mechanisms, and emerging therapeutic strategies

Figure from Journal of the Formosan Medical Association

ReviewBlood and immune system

Paper

Sunday, August 30

International ImmunopharmacologyAug 30

Targeting the macrophage-NLRP3 inflammasome-pyroptosis axis: Metformin-capped silver nanoparticles as a novel therapy for premature ovarian insufficiency

Figure from International Immunopharmacology

Experiments in ratsPremature ovarian insufficiency

Paper

Friday, August 28

Frontiers in MicrobiologyAug 28

High-fructose diet-induced gut dysbiosis as a mechanistic driver of chronic inflammation and accelerated biological aging: a comprehensive review

High-fructose diet–induced perturbation of intestinal microecology and initiation of the gut–liver inflammatory axis.

ReviewMicrobiome composition

Paper

Thursday, August 27

NutrientsAug 27

Medicinal Plant Polysaccharides as Microbiota-Directed Modulators of Immunosenescence: Structural Determinants, Metabolite Reprogramming, and Host Immune Regulation

Schematic illustration of the structure–microbiota–metabolite–immunity axis through which MPPs may function as microbiota-directed modulators of immunosenescence.

ReviewTryptophan–kynurenine metabolism

Paper

BiomedicinesAug 27

Perirenal Adipose Tissue in Cardiovascular Disease: From Molecular Insights to Therapeutic Perspectives

ReviewMechanisms

Paper

BiomoleculesAug 27

The Role of Skeletal Muscle Mitochondria in NLRP3 Inflammasome Signaling

ReviewNLRP3 inflammasome

Paper

Tuesday, August 25

Uluslararası Sağlık Bilimlerinde Disiplinler Arası Etkileşim DergisiAug 25

The Role of NLRP3 Inflammasome in Aging and Age-Related Diseases

Systematic reviewNLRP3 inflammasome

Paper

Monday, August 24

Current NeuropharmacologyAug 24

Metformin in Neurodegenerative Diseases: Mechanisms and Therapeutic Implications

ReviewMetformin

Paper

Saturday, August 22

Preprints.orgAug 22

Targeting Metainflammation in Hidradenitis Suppurativa: The Emerging Role of GLP-1 Receptor Agonists and Metabolic Pharmacotherapies

Preprint: reviewGLP-1 receptor agonists

Paper

Biochemical PharmacologyAug 22

Immunopharmacological reprogramming of innate immune memory in Alzheimer's disease: From microglial priming to therapeutic resilience

ReviewAlzheimer's disease

Paper

Translational Stroke ResearchAug 22

Therapeutic Potential of NLRP3 Inhibitor MCC950 in Aging Mice Stroke Outcomes

Figure from Translational Stroke Research

Experiments in miceStroke

Paper

Wednesday, August 19

Ageing Research ReviewsAug 19

Tryptophan metabolism regulates immunosenescence and inflammaging: The macrophage immunometabolic axis and therapeutic targets

ReviewTryptophan–kynurenine metabolism

Paper

Tuesday, August 18

Cell Biochemistry and FunctionAug 18

TET2 as a Context-Dependent Epigenetic Integrator in Clonal Hematopoiesis, Inflammation, Cancer, and Immunotherapy

ReviewInflammation

Paper

Vestnik OftalmologiiAug 18

Glaucoma and age-related macular degeneration: challenges and prospects for prevention and treatment of combined pathology. Part 1. Epidemiology and pathogenesis

ReviewEye

Paper

Monday, August 17

GerontologyAug 17

Mitochondrial Dysfunction as a Central Hub of Aging: From Molecular Cascades to Inter-Organ Communication Networks

ReviewMitochondrion

Paper

American Journal of Physiology Endocrinology and MetabolismAug 17

Mechanistic drivers of thermogenic adipose tissue dysfunction in aging and obesity

ReviewAutophagy

Paper

Thursday, August 13

Experimental GerontologyAug 13

Mitochondrial dysfunction as a key mediator of endplate chondrocyte senescence: emerging insights and targeted interventions

ReviewOxidative phosphorylation

Paper

International Journal of Molecular SciencesAug 13

Estrogen Withdrawal-Induced Cognitive Impairment in Menopausal Women: Mechanisms and Prospects for Integrated Interventions

Changes in estradiol and progesterone concentrations throughout the female menstrual cycle (follicular phase, periovulatory phase, and luteal phase).

ReviewMechanisms

Paper

CellsAug 13

Mitochondrial Dysfunction as a Driver of Meta-Inflammation in Aging: The Emerging Role of PDK4 in Bioenergetic Reprogramming and Inflammatory Amplification

Mitochondrial dysfunction as a central driver of meta-inflammation in aging.

ReviewInflammation

Paper

Tuesday, August 11

Ageing Research ReviewsAug 11

Clonal hematopoiesis of undetermined potential as an emerging determinant of inflammageing, and age-related diseases: Potential role as biomarker and target

ReviewInflammation

Paper

Saturday, August 8

Journal of Holistic Integrative PharmacyAug 8

Sterile inflammation and cognitive decline: Dissecting the HMGB1-RAGE-NLRP3 signaling cascade in the aging brain

Systematic reviewAGE–RAGE signaling

Paper

Thursday, August 6

Molecular NeurobiologyAug 6

Exercise-Mediated Modulation of the NLRP3 Inflammasome in Aging and Neurodegenerative Diseases: Mechanisms, Microglial Crosstalk, and Translational Perspectives

ReviewExercise

Paper

Monday, August 3

Problemy EndokrinologiiAug 3

Metformin's disruption of gluconeogenesis in type 2 diabetes impairments of the cori and alanine cycles as hidden drivers of metabolic waste accumulation, NF-κBHIF-1α-mediated low-grade inflammation, and multisystem dysfunction

ReviewMetformin

Paper