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NLRP3 inflammasome

There are 17 papers on NLRP3 inflammasome in aging research: 2 trials and 1 observational study in people, 13 in animals, 1 review. The newest story, Oct 26, 2026: “A liver protein is linked to coronary artery disease risk”.

Biomarker

17 papers study it524 more mention it2 findings

40 new papers in 30 daysSee all 541 papers on NLRP3 inflammasome

  • Human trial2
  • Humans1
  • Animals13

Interventions

2

Alternate-day fasting

downin mice1

1 study

  1. Alternate-day fasting decreases NLRP3 inflammasome in NOD mice with newly established Sjögren's syndrome.

    “decreased expression and activity of NLRP3 inflammasomes in the SMGs”

    Animalsin NOD mice with newly established Sjögren's syndromesubmandibular gland

    The impact of alternate-day fasting on the salivary gland stem cell compartments in non-obese diabetic mice with newly established Sjögren's syndrome

    Biochimica et biophysica acta. Molecular cell research

More on Alternate-day fasting

Tai chi

downin humans1

1 study

  1. Tai chi decreases NLRP3 inflammasome in humans (before and after 12 weeks of intervention; stated as a possible mechanism).

    “by reducing the level of NLRP3 inflammasome and its related inflammatory factors”

    Human trialbefore and after 12 weeks of intervention; stated as a possible mechanism12 weeksn = 40

    The effect of tai chi intervention on NLRP3 and its related antiviral inflammatory factors in the serum of patients with pre-diabetes

    Frontiers in immunology

More on Tai chi

Funding

3 grants since 2018

National Institute on Aging$939KNational Institute of Neurological Disorders and Stroke$35.5KWellcome Trust

Latest

Dec 2025: 6Jan 2026: 22Feb 2026: 32Mar 2026: 18Apr 2026: 13May 2026: 14Jun 2026: 13Jul 2026: 17Aug 2026: 25Sep 2026: 20Oct 2026: 34Nov 2026: 8222 papers in 12 months
ESC Congress 2026 Abstract

A liver protein is linked to coronary artery disease risk

In an analysis of 278 patients with heart disease and biobank data, genetic regulation of a liver-derived protein was associated with higher artery disease risk.In an analysis of 278 patients with heart disease and biobank data, genetic regulation of a liver-derived protein was associated with higher artery disease risk.

Mendelian randomization · 278 peopleMechanisms
Paper
Renal Failure

Gut microbe-derived compound promotes kidney aging in mice

Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks.Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks.

Mouse studyKidney
Paper

See all 541 papers on NLRP3 inflammasome

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