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NLRP3 inflammasome

Papers on NLRP3 inflammasome

541 papers40 new in 30 days

Monday, November 9

Renal Failure

Gut microbe-derived compound promotes kidney aging in mice

Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks.Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks.

Mouse studyKidney
Paper

Thursday, November 5

Wednesday, November 4

Tuesday, November 3

Thursday, October 29

Wednesday, October 28

Advanced Functional Materials

Targeted gel preserves spinal disc height in rats

In rats with puncture-damaged spinal discs, a gel targeting cells that had stopped dividing preserved imaging signals and reduced inflammatory immune-cell infiltration.In rats with puncture-damaged spinal discs, a gel targeting cells that had stopped dividing preserved imaging signals and reduced inflammatory immune-cell infiltration.

Figure from Advanced Functional Materials
Rat studyInterventions
Paper

Tuesday, October 27

Monday, October 26

ESC Congress 2026 Abstract

Exercise may protect hearts partly via a brown fat molecule in mice

In mice with diabetic heart disease, removing brown fat blunted the protective effects of voluntary exercise by causing a shortage of the signaling molecule maresin 2.In mice with diabetic heart disease, removing brown fat blunted the protective effects of voluntary exercise by causing a shortage of the signaling molecule maresin 2.

Heart cross-sections contrast intact muscle with scarred, inflamed tissue beside a mouse running in a wheel and a cluster of fat cells.
Mouse studyExercise
Paper
ESC Congress 2026 Abstract

Blood-cell mutation worsened aortic aneurysms in mice

After bone marrow transplantation and four weeks of hormone infusion, mice with an Asxl1 mutation developed more aneurysms and ruptures than controls.After bone marrow transplantation and four weeks of hormone infusion, mice with an Asxl1 mutation developed more aneurysms and ruptures than controls.

A swollen, ruptured aorta surrounded by many immune cells sits beside a smaller intact aorta with fewer cells and a laboratory mouse.
Mouse studyAbdominal aortic aneurysm
Paper
ESC Congress 2026 Abstract

A liver protein is linked to coronary artery disease risk

In an analysis of 278 patients with heart disease and biobank data, genetic regulation of a liver-derived protein was associated with higher artery disease risk.In an analysis of 278 patients with heart disease and biobank data, genetic regulation of a liver-derived protein was associated with higher artery disease risk.

A coronary artery narrowed by plaque holds dense protein clusters beside a liver and a smaller, open artery with fewer proteins.
Mendelian randomization · 278 peopleMechanisms
Paper