Inflammatory proteins are associated with principal component-based DNAm clocks in humans.
“55 of the 68 inflammatory proteins investigated were significantly associated with at least one of six DNAm aging metrics in age and sex adjusted models”
In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.
The combined regimen lowered TMAO accumulation and suppressed inflammatory signaling more effectively than cognitive training alone.The combined regimen lowered TMAO accumulation and suppressed inflammatory signaling more effectively than cognitive training alone.