Inflammatory proteins

Biomarker

5 papers2 findings

  • Humans3
  • Animals1
  • In silico1

Interventions

1

Human adipose-derived stem cell small extracellular vesicles

downin mice1

1 study
  1. Human adipose-derived stem cell small extracellular vesicles decrease inflammatory proteins in mice.

    “Proteomics revealed that hASC-sEVs reduce inflammatory proteins (TNF-α, IL-1β, IFNG, CCL2)”

    Animalscontrolled cortical impactsmall extracellular vesiclesbrain20 μg30 days post injurymales

    Human Adipose-Stem-Cell-Derived Small Extracellular Vesicles Modulate Behavior and Glial Cells in Young and Aged Mice Following TBI

    Cells22 Aug 2025

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Associations

1

Principal component-based DNAm clocks

upin humans1

1 study
  1. Inflammatory proteins are associated with principal component-based DNAm clocks in humans.

    “55 of the 68 inflammatory proteins investigated were significantly associated with at least one of six DNAm aging metrics in age and sex adjusted models”

    Humansaverage of 6 years later

    Immune cells and inflammatory proteins are differentially associated with subsequent DNA methylation biological aging measures in the Framingham Heart Study Offspring Cohort

    GeroScience2 Oct 2025

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Latest

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medRxiv

ASXL1-mutant clonal hematopoiesis links to aortic valve disease

In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.

Preprint: cohort study of 449,109 peopleASXL1