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Human adipose-derived stem cell small extracellular vesicles

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: U.S. Department of Veterans Affairs
  • Animals1

Outcomes

4

Inflammatory proteins

downin mice1

1 study

  1. Human adipose-derived stem cell small extracellular vesicles decrease inflammatory proteins in mice.

    “Proteomics revealed that hASC-sEVs reduce inflammatory proteins (TNF-α, IL-1β, IFNG, CCL2)”

    Animalscontrolled cortical impactsmall extracellular vesiclesbrain20 μg30 days post injurymales

    Human Adipose-Stem-Cell-Derived Small Extracellular Vesicles Modulate Behavior and Glial Cells in Young and Aged Mice Following TBI

    Cells22 Aug 2025

More on Inflammatory proteins

Motor function

upin mice1

1 study

  1. Human adipose-derived stem cell small extracellular vesicles improve motor function in mice.

    “improving motor function, reducing neuroinflammation, and enhancing neurogenesis”

    Animalscontrolled cortical impactsmall extracellular vesiclesbrain20 μg7 days post injurymales

    Human Adipose-Stem-Cell-Derived Small Extracellular Vesicles Modulate Behavior and Glial Cells in Young and Aged Mice Following TBI

    Cells22 Aug 2025

Inflammation

downin mice1

1 study

  1. Human adipose-derived stem cell small extracellular vesicles decrease inflammation in mice.

    “reduced neuroinflammatory markers (GFAP, IBA-1, and MHC-II), with reduced efficacy observed in older mice”

    Animalscontrolled cortical impactsmall extracellular vesiclesbrain20 μg7 to 30 days post injurymales

    Human Adipose-Stem-Cell-Derived Small Extracellular Vesicles Modulate Behavior and Glial Cells in Young and Aged Mice Following TBI

    Cells22 Aug 2025

More on Inflammation

Behavioral outcomes

upin mice1

1 study

  1. Human adipose-derived stem cell small extracellular vesicles improve behavioral outcomes in mice.

    “hASC-sEV treatment significantly improved behavioral outcomes”

    Animalscontrolled cortical impactsmall extracellular vesiclesbrain20 μg7 to 30 days post injurymales

    Human Adipose-Stem-Cell-Derived Small Extracellular Vesicles Modulate Behavior and Glial Cells in Young and Aged Mice Following TBI

    Cells22 Aug 2025

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