Nature Communications

Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice

By Brittany M. Hemmer, Sarah M. Philippi, Ana Catarina Ferreira, Joseph M. Castellano

Experiments in miceMechanisms

The paper

Brittany M. Hemmer, Sarah M. Philippi, Ana Catarina Ferreira, Joseph M. Castellano

Icahn School of Medicine at Mount Sinai

Nature Communications, 12 Aug 2026

doi.org/10.1038/s41467-026-74906-z PubMed 42586968

bioRxiv2 Oct 2026
Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice
Glia2 Oct 2026
Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice
bioRxiv2 Oct 2026
CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice
bioRxiv2 Oct 2026
Astrocytic secretome enhances hippocampal neurogenesis and spatial memory in mice