Principal component-based DNAm clocks

1. Inflammatory proteins are associated with principal component-based DNAm clocks in humans.

   “55 of the 68 inflammatory proteins investigated were significantly associated with at least one of six DNAm aging metrics in age and sex adjusted models”

   Humansaverage of 6 years later

   Immune cells and inflammatory proteins are differentially associated with subsequent DNA methylation biological aging measures in the Framingham Heart Study Offspring Cohort

   GeroScience·2 Oct 2025

More on Inflammatory proteins

1. Immune cell composition is associated with principal component-based DNAm clocks in humans.

   “A total of 24 of the 43 immune cell phenotypes and 55 of the 68 inflammatory proteins investigated were significantly associated with at least one of six DNAm aging metrics”

   Humansaverage of 6 years later

   Immune cells and inflammatory proteins are differentially associated with subsequent DNA methylation biological aging measures in the Framingham Heart Study Offspring Cohort

   GeroScience·2 Oct 2025

More on Immune cell composition