Hepatocyte growth factor

There are 19 papers on hepatocyte growth factor in aging research: 1 trial and 9 observational studies in people, 6 in animals, 2 in cells. The newest story, Nov 10, 2026: “Restoring cell cleanup helped lung scarring resolve in mice”.

Biomarker

19 papers study it48 more mention it5 findings

MeSH

2 new papers in 30 daysSee all 67 papers on hepatocyte growth factor

“hepatocyte growth factor (HR=1.12; 95% CI 1.05, 1.19)”
Inflammatory proteomics profiling for prediction of incident atrial fibrillationHeart (British Cardiac Society)2023doi:10.1136/heartjnl-2022-321959
  • Human trial1
  • Humans9
  • Animals6
  • Cells2

Interventions

1

Adipose-derived stem cell / endothelial colony-forming cell 3d co-culture

upin human cells1

1 study
  1. Adipose-derived stem cell / endothelial colony-forming cell 3d co-culture increases hepatocyte growth factor in human cells (compared with single-cell 3D culture or monolayer culture).

    “The ASC/ECFC co-culture increased the secretion of cytokines, such as hepatocyte growth factor, compared with single-cell 3D culture or monolayer culture”

    Cellscompared with single-cell 3D culture or monolayer culture

    3D co-culture model of endothelial colony-forming cells (ECFCs) reverses late passage adipose-derived stem cell senescence for wound healing

    Stem cell research & therapy

More on Adipose-derived stem cell / endothelial colony-forming cell 3d co-culture

Associations

4

Frontal white matter volume

downin humans1

1 study
  1. Hepatocyte growth factor is associated with frontal white matter volume in humans.

    “higher HGF, IL8, and MMP10 were associated with smaller TCBV, total and frontal white matter volumes”

    Humanswhite matter

    Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort

    Alzheimer's & dementia : the journal of the Alzheimer's Association

More on Frontal white matter volume

Appendicular lean mass

upin humans1OR 1.03

1 study
  1. Hepatocyte growth factor is associated with appendicular lean mass in humans (OR = 1.03, P = 0.002).

    “hepatocyte growth factor (HGF) (OR = 1.03, P = 0.002) demonstrated positive associations with ALM”

    Humans

    Association between immune cells, inflammatory cytokines, and sarcopenia: Insights from a Mendelian randomization analysis

    Archives of gerontology and geriatrics

Atrial fibrillation

upin humans1HR 1.12

1 study
  1. Hepatocyte growth factor is linked with a higher risk of atrial fibrillation in humans (adjusted for sex and age) (HR=1.12; 95% CI 1.05, 1.19).

    “hepatocyte growth factor (HR=1.12; 95% CI 1.05, 1.19)”

    Humansadjusted for sex and agen = 10,744

    Inflammatory proteomics profiling for prediction of incident atrial fibrillation

    Heart (British Cardiac Society)

More on Atrial fibrillation

Vitamin D

upin humans1

1 study
  1. Vitamin D is associated with hepatocyte growth factor in humans across 25(OH)D tertiles, adjusted for age, sex, BMI and McAuley's index (T1 > T3, p = 0.009).

    “HGF (T1 > T3, p = 0.009)”

    Humansacross 25(OH)D tertiles, adjusted for age, sex, BMI and McAuley's indexn = 83

    The Association of Vitamin D Status with Dyslipidaemia and Biomarkers of Endothelial Cell Activation in Older Australians

    Nutrients

More on Vitamin D

Funding

2 grants since 2018

National Institute on Aging$172KUS Department of Veterans Affairs

Latest

Dec 2025: 2Jan 2026: 1Feb 2026: 0Mar 2026: 0Apr 2026: 1May 2026: 4Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 110 papers in 12 months
PNAS

Restoring cell cleanup helped lung scarring resolve in mice

Animal experiments linked persistent lung scarring to poor clearance of dying cells, while activating a metabolic regulator promoted scarring resolution in aged mice.Animal experiments linked persistent lung scarring to poor clearance of dying cells, while activating a metabolic regulator promoted scarring resolution in aged mice.

Mouse studyLung

See all 67 papers on hepatocyte growth factor