Free cholesterol

Biomarker1 paper1 finding

  • Animals1

Interventions

1

Caloric restriction

upin mice1

1 study
  1. Caloric restriction increases free cholesterol in mice.

    Animalsin ApoE-deficient mice fed HCHF dietliversix months

    Mild caloric restriction accelerates atherosclerosis in mice · JCI insight · 22 Sep 2026

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Alzheimer's & DementiaHumans

HDL particle sizes show contrasting links to dementia risk

In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk…In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk (1.10 to 1.14).

JCI InsightAnimals

Mild caloric restriction accelerates atherosclerosis in mice

In ApoE-deficient mice fed for six months, mild food restriction reduced weight gain by 5% but increased circulating cholesterol and accelerated…In ApoE-deficient mice fed for six months, mild food restriction reduced weight gain by 5% but increased circulating cholesterol and accelerated plaque formation.