The journal of prevention of Alzheimer's disease·1 Jan 2024
Simpler N-glycans cluster
↑upin humans1
1 study
Simpler N-glycans cluster is associated with comorbidity index in humans.
“The individuals of the first cluster were older, showed higher concentrations of glucose and glycation markers, higher levels of some inflammatory markers, lower glomerular filtration rate, and greater comorbidity index”
Median age at diagnosis rose from 63.0 years in 2005–2008 to 66.7 years in 2020–2023, alongside more coexisting illnesses and lower blood sugar.Median age at diagnosis rose from 63.0 years in 2005–2008 to 66.7 years in 2020–2023, alongside more coexisting illnesses and lower blood sugar.
Cohort study of 181,593 adults with newly diagnosed type 2 diabetesType 2 diabetes
Limit: More complete case ascertainment among older adults could contribute to the apparent age shift
Estimated five-year survival was 85.9% with scores of 3 to 4 for coexisting illnesses, versus 50.1% with scores of 7 or higher.Estimated five-year survival was 85.9% with scores of 3 to 4 for coexisting illnesses, versus 50.1% with scores of 7 or higher.
Preprint: cohort study of 709 older Thai adults with positive screening FOBT, against adults with CCI 3–4Populations
Limit: Excluding patients with missing baseline clinical records may bias the illness–survival association
The hazard ratio for death—a relative rate over time—was 1.43 for illness scores of one and 1.88 for two or more, versus zero.The hazard ratio for death—a relative rate over time—was 1.43 for illness scores of one and 1.88 for two or more, versus zero.
Cohort study of 539 people aged 80+ with large B-cell lymphoma, against patients with LCI score 0Biomarkers
Limit: Overall survival includes deaths unrelated to lymphoma, not just deaths from lymphoma
An observational study of 100 people with colorectal cancer linked higher blood levels of an immune protein to more severe frailty.An observational study of 100 people with colorectal cancer linked higher blood levels of an immune protein to more severe frailty.
Cross-sectional study of 100 patients with colorectal cancerImmune response
Limit: Dietary intake, anticancer drug use, and baseline nutritional status could confound the association
The best model scored 0.917 on a measure of how well it separated patients with and without frailty, in 124 patients from another city.The best model scored 0.917 on a measure of how well it separated patients with and without frailty, in 124 patients from another city.