Glomerular filtration rate
Biomarker4 papers2 findingsMeSH D005919
- Humans2
- Animals1
Interventions
1HFI-419
downin mice1Very low certainty
1 study
HFI-419
downin mice1Very low certainty
HFI-419 prevents glomerular filtration rate in mice.
Animalskidney500 ng/kg/min4 weeks
IRAP deficiency preserves renal function and attenuates pathology in aged mice · Clinical science (London, England : 1979) · 3 Sep 2026
Associations
1Mortality
downin humans1
1 study
Mortality
downin humans1
Glomerular filtration rate lowers the risk of mortality in humans (2.53 times higher risk for GFR < 7 vs > 10).
HumansGFR < 7 vs > 10 mL/min/1.73 m2 at hemodialysis initiation
Evaluation of the Effects of Glomerular Filtration Rate, Neutrophil-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio on Mortality at the Initiation of Hemodialysis · Research Square · 9 Sep 2026 · Preprint
Latest
166Organ aging measures have varied genetic links to disease
An analysis using inherited genetic differences prioritised 31 of 306 assessable comparisons between organ aging measures and age-related conditions…An analysis using inherited genetic differences prioritised 31 of 306 assessable comparisons between organ aging measures and age-related conditions in European-ancestry datasets.
Blood protein links to heart attacks vary with kidney function
Links to heart attacks were stronger at lower kidney function for 154 blood proteins and at higher function for 22.Links to heart attacks were stronger at lower kidney function for 154 blood proteins and at higher function for 22.
Age-related differences in renal function decline and associated factors in type 2 diabetes mellitus: A prospective cohort study
Fractional uric acid excretion linked to kidney function decline
Higher fractional uric acid excretion was associated with eGFR decline after adjustment for confounders (odds ratio 1.218, 95% CI 1.176–1.262).Higher fractional uric acid excretion was associated with eGFR decline after adjustment for confounders (odds ratio 1.218, 95% CI 1.176–1.262).
Renal Function, Appendicular Lean Mass, and Bone Stiffness: Indirect Associations Through Fibroblast Growth Factor 21
Underweight is linked to higher kidney disease risk in diabetes
Underweight carried an odds ratio of 1.41 for incident chronic kidney disease compared with no obesity, whereas excess adiposity showed an odds ratio…Underweight carried an odds ratio of 1.41 for incident chronic kidney disease compared with no obesity, whereas excess adiposity showed an odds ratio of 1.03.
Plasma p-tau217 yields discordant Alzheimer results in 8.5% of adults
False-negative blood results occurred in 5.6% of participants compared with false positives in 2.8%, with mismatches tied to kidney function, BMI, and…False-negative blood results occurred in 5.6% of participants compared with false positives in 2.8%, with mismatches tied to kidney function, BMI, and clinical stage.